Hand, foot and mouth disease and herpangina caused by enterovirus A71 infections: a review of enterovirus A71 molecular epidemiology, pathogenesis, and current vaccine development
| Autor: | Kou-Huang Chen, Kow-Tong Chen, Yu-Kang Chang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Herpangina lcsh:Arctic medicine. Tropical medicine lcsh:RC955-962 Enterovirus A71 foot and mouth disease Review Virus Pathogenesis 03 medical and health sciences medicine Enterovirus Infections Humans Pathogen Molecular Epidemiology Communicable disease Molecular epidemiology Foot-and-mouth disease business.industry Mortality rate Viral Vaccines medicine.disease Hand Virology Enterovirus A Human 030104 developmental biology business Hand foot and mouth disease Vaccine |
| Zdroj: | Revista do Instituto de Medicina Tropical de São Paulo; Vol. 60 (2018); e70 Revista do Instituto de Medicina Tropical de São Paulo; v. 60 (2018); e70 Revista do Instituto de Medicina Tropical de São Paulo Instituto de Medicina Tropical (IMT) instacron:IMT Revista do Instituto de Medicina Tropical de São Paulo, Vol 60, Iss 0 (2018) |
| ISSN: | 1678-9946 0036-4665 |
| Popis: | Enterovirus A71 (EV-A71) infections are one of the main etiological agents of hand, foot and mouth disease (HFMD) and herpangina worldwide. EV-A71 infection is a life-threatening communicable disease and there is an urgent global need for the development of vaccines for its prevention and control. The morbidity rate of EV-A71 infection differs between countries. The pathogen’s genetic lineages are undergoing rapid evolutionary changes. An association between the occurrence of EV-A71 infection and the circulation of different genetic strains of EV-A71 virus has been identified around the world. In this review, we present and discuss the molecular epidemiology and pathogenesis of the human disease caused by EV-A71 infection, as well as current prospects for the development of an EV-A71 vaccine. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|