Seroprevalence of Bordetella pertussis antibodies in Flanders (Belgium)
| Autor: | Claire-Anne Siegrist, Marie Van der Wielen, Susanna E. Schlegel-Haueter, Pierre Van Damme, Koen Van Herck |
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| Rok vydání: | 2003 |
| Předmět: |
Adult
Male Bordetella pertussis Adolescent Whooping Cough Population Filamentous haemagglutinin adhesin ddc:616.07 Pertussis toxin complex mixtures Whooping Cough/epidemiology Serology Age Distribution Belgium Seroepidemiologic Studies Humans Medicine Seroprevalence Child education Belgium/epidemiology Whooping cough education.field_of_study ddc:618 General Veterinary General Immunology and Microbiology biology business.industry Public Health Environmental and Occupational Health Infant Reproducibility of Results Antibodies Bacterial/blood Middle Aged biology.organism_classification medicine.disease Antibodies Bacterial Infectious Diseases Child Preschool Immunology Molecular Medicine Female Pertactin business |
| Zdroj: | Vaccine, Vol. 21, No 19-20 (2003) pp. 2412-7 Vaccine |
| ISSN: | 0264-410X |
| DOI: | 10.1016/s0264-410x(03)00062-8 |
| Popis: | To determine age-dependent pertussis immune response in the Flemish population, antibody levels to pertactin (PRN), pertussis toxin (PT) and filamentous hemagglutinin (FHA) were measured in serum samples from 1622 healthy 1-100-year-old subjects. For anti-PRN and anti-PT antibodies, peaks in GMTs were seen in infancy and again in the 10-15-year age group. After age of 20 years, anti-PRN GMT declined rapidly over a decade, followed by a slower decline. Anti-FHA GMT tended to rather increase progressively with age. These data confirm waning of vaccine-induced antibody levels and suggest pertussis resurgence during adolescence and young adulthood. These results support a pertussis booster vaccination policy for adolescents and adults. |
| Databáze: | OpenAIRE |
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