Endothelial Nitric Oxide Synthase Polymorphisms and Adaptation of Parasympathetic Modulation to Exercise Training
| Autor: | Carlos Eduardo Negrão, Marcelo V. Negrao, Bruno M. Silva, Guilherme Barreto Alves, Alexandre C. Pereira, Antonio Claudio Lucas da Nobrega, José Eduardo Krieger, Fabricia J. Neves, Cleber Renê Alves, Rodrigo Gonçalves Dias, Maria Urbana P. B. Rondon |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male medicine.medical_specialty Nitric Oxide Synthase Type III Blood Pressure Physical Therapy Sports Therapy and Rehabilitation Baroreflex Running Young Adult Oxygen Consumption Heart Rate Parasympathetic Nervous System Interquartile range Polymorphism (computer science) Internal medicine medicine Humans Aerobic exercise Orthopedics and Sports Medicine Allele Polymorphism Genetic business.industry Haplotype Wild type Adaptation Physiological Autonomic nervous system Endocrinology Haplotypes business TREINAMENTO FÍSICO |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 0195-9131 |
| Popis: | Purpose: There is a large interindividual variation in the parasympathetic adaptation induced by aerobic exercise training, which may be partially attributed to genetic polymorphisms. Therefore, we investigated the association among three polymorphisms in the endothelial nitric oxide gene (-786T>C, 4b4a, and 894G>T), analyzed individually and as haplotypes, and the parasympathetic adaptation induced by exercise training. Methods: Eighty healthy males, age 20-35 yr, were genotyped by polymerase chain reaction-restriction fragment length polymorphism analysis, and haplotypes were inferred using the software PHASE 2.1. Autonomic modulation (i.e., HR variability and spontaneous baroreflex sensitivity) and peak oxygen consumption (V?O2peak) were measured before and after training (running, moderate to severe intensity, three times per week, 60 min·day-1, during 18 wk). Results: Training increased V?O2peak (P < 0.05) and decreased mean arterial pressure (P < 0.05) in the whole sample. Subjects with the -786C polymorphic allele had a significant reduction in baroreflex sensitivity after training (change: wild type (-786TT) = 2% ± 89% vs polymorphic (-786TC/CC) = -28% ± 60%, median ± quartile range, P = 0.03), and parasympathetic modulation was marginally reduced in subjects with the 894T polymorphic allele (change: wild type (894GG) = 8% ± 67% vs polymorphic (894GT/TT) = -18% ± 59%, median ± quartile range, P = 0.06). Furthermore, parasympathetic modulation percent change was different between the haplotypes containing wild-type alleles (-786T/4b/894G) and polymorphic alleles at positions -786 and 894 (-786C/4b/894T) (-6% ± 56% vs -41% ± 50%, median ± quartile range, P = 0.04). Conclusions: The polymorphic allele at position -786 and the haplotype containing polymorphic alleles at positions -786 and 894 in the endothelial nitric oxide gene were associated with decreased parasympathetic modulation after exercise training. |
| Databáze: | OpenAIRE |
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