Adding myofibroblasts to the lacrimal pump
| Autor: | Liliana Voinea, Mugurel Constantin Rusu, Raluca Iustina Bâră, Alexandra Diana Vrapciu |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male Pathology medicine.medical_specialty Histology Vascular smooth muscle Stromal cell Myocytes Smooth Muscle 03 medical and health sciences 0302 clinical medicine medicine Humans Myofibroblasts Retrospective Studies Nasolacrimal duct Chemistry Myoepithelial cell Lacrimal Apparatus Epithelial Cells Cell Biology General Medicine Middle Aged Lacrimal sac Actins 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Immunohistochemistry Tears Calmodulin-Binding Proteins Female Pericytes Myofibroblast Muscle Contraction |
| Zdroj: | Acta histochemica. 122(4) |
| ISSN: | 1618-0372 |
| Popis: | The lacrimal sac (LS) empties in the nasolacrimal duct to drain the tears in the inferior nasal meatus. Different studies indicated the role of the lacrimal pump in the lacrimal drainage. Although controversial, the lacrimal pump mechanism is an extrinsic one, either active, or passive. An intrinsic contractile potential of the LS was not documented previously. We thus aimed a retrospective immunohistochemical study to test the alpha-smooth muscle actin (α-SMA) and h-caldesmon expression in the LS wall. We used archived paraffin-embedded samples of LS from ten adult patients. The α-SMA + phenotype was detected in basal epithelial cells, in subepithelial ribbons of stromal cells, in vascular smooth muscle cells, as well as in pericytes. H-caldesmon was exclusively expressed in pericytes, vascular smooth muscle cells and myoepithelial cells of the subepithelial glands. The most striking feature we found in all samples was a consistent stromal network of α-SMA+/h-caldesmon- myofibroblasts. This finding supports an intrinsic scaffold useful for the lacrimal pump. |
| Databáze: | OpenAIRE |
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