Some biological and pharmacological properties of inflammatory exudates
| Autor: | Bryan V. Robinson, N S Doherty |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Exudate
Male Serotonin Time Factors Pharmaceutical Science Bradykinin Vascular permeability Pharmacology Biology Carrageenan Capillary Permeability chemistry.chemical_compound In vivo medicine Animals Edema Prostaglandin E1 Pleurisy Glucuronidase Inflammation L-Lactate Dehydrogenase Prostaglandins E Complement System Proteins Exudates and Transudates medicine.disease Blood Cell Count Rats chemistry Immunology medicine.symptom Histamine |
| Zdroj: | The Journal of pharmacy and pharmacology. 28(12) |
| ISSN: | 0022-3573 |
| Popis: | Inflammatory exudates were obtained from polyester sponges which had been implanted subcutaneously in rats four days previously. This material was found to be anti-inflammatory when injected into other rats in which carrageenan pleurisy had been induced. At a dose of 600 mg kg−1 exudate inhibited the formation of pleural effusion, emigration of both neutrophils and mononuclear cells and the accumulation of β-glucuronidase and lactic dehydrogenase. The same dose of sponge exudate did not however inhibit the increased vascular permeability induced in the rat skin or rat foot following injection of 5-hydroxytryptamine, histamine, prostaglandin E1, or bradykinin. Furthermore sponge exudate did not reduce the haemolytic complement titre of rat serum either in vivo or in vitro. The possible mechanism of anti-inflammatory action of exudate is discussed. |
| Databáze: | OpenAIRE |
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