Effect of PCSK9 Inhibitors on Clinical Outcomes in Patients With Hypercholesterolemia: A Meta-Analysis of 35 Randomized Controlled Trials
| Autor: | Houman Khalili, Zahid Ahmad, Michael D. Miedema, Judit Karacsonyi, Bavana V. Rangan, Subhash Banerjee, Thomas Knickelbine, Michele Roesle, Emmanouil S. Brilakis, Shuaib M Abdullah, Barbara A. Danek, Aris Karatasakis |
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| Rok vydání: | 2017 |
| Předmět: |
Oncology
medicine.medical_specialty Hypercholesterolemia alirocumab 030204 cardiovascular system & hematology Antibodies Monoclonal Humanized law.invention PCSK9 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law Risk Factors Internal medicine medicine Secondary Prevention Humans hyperlipidemia 030212 general & internal medicine PCSK9 Inhibitors Alirocumab Randomized Controlled Trials as Topic Systematic Review and Meta‐Analysis Lipids and Cholesterol business.industry Anticholesteremic Agents Meta Analysis Antibodies Monoclonal Proprotein convertase Primary Prevention Evolocumab Treatment Outcome evolocumab Meta-analysis outcome Kexin Proprotein Convertase 9 Cardiology and Cardiovascular Medicine business |
| Zdroj: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| ISSN: | 2047-9980 |
| Popis: | Background We sought to examine the efficacy and safety of 2 PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibitors: alirocumab and evolocumab. Methods and Results We performed a systematic review and meta‐analysis of randomized controlled trials comparing treatment with and without PCSK9 inhibitors; 35 randomized controlled trials comprising 45 539 patients (mean follow‐up: 85.5 weeks) were included. Mean age was 61.0±2.8 years, and mean baseline low‐density lipoprotein cholesterol was 106±22 mg/dL. Compared with no PCSK9 inhibitor therapy, treatment with a PCSK9 inhibitor was associated with a lower rate of myocardial infarction (2.3% versus 3.6%; odds ratio [OR]: 0.72 [95% confidence interval (CI), 0.64–0.81]; P P =0.02), and coronary revascularization (4.2% versus 5.8%; OR: 0.78 [95% CI, 0.71–0.86]; P P =0.12) or cardiovascular mortality (OR: 1.01 [95% CI, 0.85–1.19]; P =0.95). A significant association was observed between higher baseline low‐density lipoprotein cholesterol and benefit in all‐cause mortality ( P =0.038). No significant change was observed in neurocognitive adverse events (OR: 1.12 [95% CI, 0.88–1.42]; P =0.37), myalgia (OR: 0.95 [95% CI, 0.75–1.20]; P =0.65), new onset or worsening of preexisting diabetes mellitus (OR: 1.05 [95% CI, 0.95–1.17]; P =0.32), and increase in levels of creatine kinase (OR: 0.84 [95% CI, 0.70–1.01]; P =0.06) or alanine or aspartate aminotransferase (OR: 0.96 [95% CI, 0.82–1.12]; P =0.61). Conclusions Treatment with a PCSK9 inhibitor is well tolerated and improves cardiovascular outcomes. Although no overall benefit was noted in all‐cause or cardiovascular mortality, such benefit may be achievable in patients with higher baseline low‐density lipoprotein cholesterol. |
| Databáze: | OpenAIRE |
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