Architectural proteins, transcription, and the three-dimensional organization of the genome
| Autor: | Victor G. Corces, Caelin Cubeñas-Potts |
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| Rok vydání: | 2015 |
| Předmět: |
Transcription
Genetic Biophysics Computational biology Regulatory Sequences Nucleic Acid Biology Biochemistry Article Chromatin remodeling Epigenesis Genetic Chromosome conformation capture Structural Biology Genetics Animals Humans Scaffold/matrix attachment region Molecular Biology ChIA-PET Chromatin Fiber Binding Sites Genome Human Topologically associating domain Cell Biology ChIP-on-chip CCCTC-binding factor Chromatin ChIP-sequencing DNA-Binding Proteins Nucleic Acid Conformation Epigenetics Insulator Protein Binding |
| Zdroj: | FEBS Letters. 589:2923-2930 |
| ISSN: | 0014-5793 |
| DOI: | 10.1016/j.febslet.2015.05.025 |
| Popis: | Architectural proteins mediate interactions between distant sequences in the genome. Two well-characterized functions of architectural protein interactions include the tethering of enhancers to promoters and bringing together Polycomb-containing sites to facilitate silencing. The nature of which sequences interact genome-wide appears to be determined by the orientation of the architectural protein binding sites as well as the number and identity of architectural proteins present. Ultimately, long range chromatin interactions result in the formation of loops within the chromatin fiber. In this review, we discuss data suggesting that architectural proteins mediate long range chromatin interactions that both facilitate and hinder neighboring interactions, compartmentalizing the genome into regions of highly interacting chromatin domains. |
| Databáze: | OpenAIRE |
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