Initiation of DNA Synthesis in Cell Cultures by Colcemid
| Autor: | V. I. Guelstein, J M Vasiliev, Gel'fand Im |
|---|---|
| Rok vydání: | 1971 |
| Předmět: |
Cell
Biology Tritium Vinblastine Microtubules Mice chemistry.chemical_compound Microtubule Culture Techniques medicine Animals Mitosis Multidisciplinary Colcemid DNA synthesis DNA Fibroblasts Embryo Mammalian Molecular biology Stimulation Chemical Cell biology Benzocycloheptenes medicine.anatomical_structure chemistry Cytoplasm Interphase Biological Sciences: Biochemistry sense organs Colchicine Thymidine medicine.drug |
| Zdroj: | Proceedings of the National Academy of Sciences. 68:977-979 |
| ISSN: | 1091-6490 0027-8424 |
| DOI: | 10.1073/pnas.68.5.977 |
| Popis: | Mitotic inhibitors (colcemid, colchicine, and vinblastine) initiate DNA synthesis in dense stationary cultures of mouse embryo fibroblast-like cells. This initiation is not due to any changes in local cell population density. Relationships between the activation of proliferation and other changes of interphase fibroblast-like cells produced by the mitotic inhibitors (disappearance of cytoplasmic microtubules and activation of movements of cell surface) are discussed. |
| Databáze: | OpenAIRE |
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