Cathepsin K expression in clear cell 'sugar' tumor (PEComa) of the lung
| Autor: | Lisa Marcolini, Matteo Brunelli, Giulio Rossi, Maurizio Pea, Claudio Ghimenton, Alberto Cavazza, Marco Chilosi, Anna Caliò, Guido Martignoni, Maria Cecilia Mengoli |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Adult Male Perivascular Epithelioid Cell Neoplasms Cathepsin K Clone (cell biology) Antigens Differentiation Myelomonocytic TFE3 Biology Translocation Genetic Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine Antigens CD medicine Biomarkers Tumor Humans PEComa Molecular Biology Lung In Situ Hybridization Fluorescence Gene Rearrangement medicine.diagnostic_test Clear cell “sugar” tumor Immunohistochemistry Cell Biology General Medicine Gene rearrangement Middle Aged Kidney Neoplasms 030104 developmental biology 030220 oncology & carcinogenesis Cancer research TFEB Female Clear cell Fluorescence in situ hybridization |
| Popis: | Clear cell "sugar" tumor is a rare benign neoplasm arising in the lung, considered as a part of the PEComa family. As PEComas of other sites, this tumor expresses melanocytic markers such as HMB45 and Melan-A. Despite cathepsin K, MITF and CD68 staining are known to be positive in a large number of PEComas and TFE3 rearrangement has been reported in a subset of PEComas, no data is available regarding the expression of these markers and the occurrence of TFE3 and TFEB rearrangement in clear cell "sugar" tumor of the lung. We have investigated the immunolabeling of cathepsin K, MITF, and CD68 in five cases of clear cell "sugar" tumor. Moreover, we have also sought the presence of TFE3 and TFEB rearrangement by fluorescence in situ hybridization (FISH) assay. In all tumors, strong immunoreactivity of cathepsin K and CD68 (PG-M1 and KP1 clone) was demonstrated, whereas none of them labeled for MITF staining and showed TFE3 or TFEB rearrangement. These findings widen the immunohistochemical profile of clear cell "sugar" tumor providing useful new markers for challenging cases. The expression of lysosomal markers, such as cathepsin K and CD68, strengthens the hypothesis that this tumor is part of the PEComa family. |
| Databáze: | OpenAIRE |
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