The effect of marinobufagenin on the growth and proliferation of cells in the organotypic culture
| Autor: | A. Ya. Bagrov, Boris V. Krylov, V. A. Penniyaynen, E. V. Lopatina, A. V. Kipenko |
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| Rok vydání: | 2015 |
| Předmět: |
Organogenesis
ATPase Chick Embryo Cell Enlargement Biology General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Organ Culture Techniques medicine Animals Cells Cultured Cell Proliferation Retina Marinobufagenin Dose-Response Relationship Drug General Immunology and Microbiology Embryo General Medicine Cell biology Bufanolides Intracellular signal transduction Dose–response relationship medicine.anatomical_structure chemistry Organ Specificity biology.protein Sodium-Potassium-Exchanging ATPase General Agricultural and Biological Sciences Function (biology) Explant culture |
| Zdroj: | Doklady Biological Sciences. 462:164-166 |
| ISSN: | 1608-3105 0012-4966 |
| DOI: | 10.1134/s0012496615030096 |
| Popis: | In recent years, a substantial interest has been aroused in investigating Na(+),K(+) ATPase as a membrane structure which not only performs its direct function in maintaining the gradients of Na(+) and K(+) concentrations, but also may participate in the intracellular signal transduction processes in response to various physiological stimuli. The effect of marinobufagenin, a digitalislike factor, on the growth and proliferation of sensory ganglia, cardiac, retina, skin, and liver tissue explants of 10-12day old chicken embryos was investigated by the organotypic culture method in a wide range of concentrations (10(-10) to 10(-4) M). It was first demonstrated that marinobufagenin inhibited the growth of the investigated tissue explants in the dosedependent but not tissuespecific manner. The experimental data obtained allow us to suggest that the mechanism of regulation of tissue growth by marinobufagenin during the embryonic period of ontogenesis is associated with the modulation of the pump function of Na(+),K(+) ATPase but not its transducing function. |
| Databáze: | OpenAIRE |
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