Study Protocol for the DETECTIVE Study: An International Collaborative Study To Develop Consensus Statements for Deferred Treatment with Curative Intent for Localised Prostate Cancer
| Autor: | Nicola Fossati, Karel Tim Buddingh, Malcolm David Mason, Karin Plass, Christian D. Fankhauser, Steven MacLennan, Michael Lardas, James N'Dow, Henk G. van der Poel, Hendrik Van Poppel, Thomas B. Lam, Philip Cornford, Thomas Van den Broeck, Alexandre Ingels, Thomas Wiegel, Niall F. Davis, Peter-Paul M. Willemse, Catherine Paterson, Olivier Rouvière, Silke Gillessen, Lisa Moris, Fabio Zattoni, Marcus G. Cumberbatch, Matthew Liew, Theodorus H. van der Kwast, Ivo G. Schoots, Jeremy Grummet, Tobias Gross, N. Grivas, Stefano Fanti, Roderick C.N. van den Bergh, Ann Henry, Paolo Dell'Oglio, N. Mottet, James Donaldson, Muhammad Imran Omar, Derya Tilki, Maria De Santis, Erik Briers, Karl H. Pang |
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| Přispěvatelé: | Radiology & Nuclear Medicine, Pathology, Lam TBL, MacLennan S, Plass K, Willemse PM, Mason MD, Cornford P, Donaldson J, Davis NF, Dell'Oglio P, Fankhauser C, Grivas N, Ingels A, Lardas M, Liew M, Pang KH, Paterson C, Omar MI, Zattoni F, Buddingh KT, Van den Broeck T, Cumberbatch MG, Fossati N, Gross T, Moris L, Schoots IG, van den Bergh RCN, Briers E, Fanti S, De Santis M, Gillessen S, Grummet JP, Henry AM, van der Poel HG, van der Kwast TH, Rouvière O, Tilki D, Wiegel T, N'Dow J, Van Poppel H, Mottet N. |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Research design
Male medicine.medical_specialty Consensus Letter Delphi Technique Consensus Development Conferences as Topic Urology education 030232 urology & nephrology Delphi method MEDLINE Prostatic Neoplasms/pathology Evidence-Based Medicine Humans Medical Oncology Multicenter Studies as Topic Prostatic Neoplasms Systematic Reviews as Topic Treatment Outcome Research Design 03 medical and health sciences 0302 clinical medicine SDG 3 - Good Health and Well-being medicine 610 Medicine & health computer.programming_language Protocol (science) business.industry Prostate Cancer Urology/standards Stakeholder Evidence-based medicine Guideline 030220 oncology & carcinogenesis Family medicine Medical Oncology/standards business computer Delphi Multicenter Studies as Topic/methods |
| Zdroj: | European Urology, 75(4), 699-702. Elsevier |
| ISSN: | 0302-2838 |
| Popis: | Deferred active treatment (DAT) strategies, including active surveillance and active monitoring, are a recognised management option for men with localised low-risk prostate cancer. However, there is uncertainty due to heterogeneity of patient selection criteria, follow-up and monitoring characteristics, reclassification thresholds, and which outcome measures should be prioritised. This protocol describes a study led by the European Association of Urology (EAU) Prostate Cancer Guidelines Panel in conjunction with other guideline organisations and societies to develop consensus statements for all domains of deferred active treatment. The project is divided into 3 sequential phases: (1) Systematic review of studies reporting on DAT in order to summarise and define range of heterogeneity regarding all domains; (2) Two-round Delphi online survey involving a large, international panel of healthcare professionals (HCPs) and patients to initiate consensus; and (3) Consensus group meeting involving representatives from HCP and patient stakeholder groups to finalise the consensus process. The consensus statements are expected to be adopted by clinical practice guidelines in order to standardise and guide practice for clinicians and researchers until better evidence emerges. Patient summary: We describe a project aimed at standardising elements of practice in active surveillance/monitoring for early localised prostate cancer, because currently there is great variation and uncertainty regarding how best to conduct them. This will be achieved through a structured process of agreement (i.e. consensus) amongst a large, international panel of healthcare professionals and patients. |
| Databáze: | OpenAIRE |
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