Hepatoprotective potential of ether insoluble phenolic components of n-butanol fraction (EPC-BF) of flaxseed against CCl4 -induced liver damage in rats
| Autor: | Keshav K. Deshmukh, Deepak M. Kasote, Anand A. Zanwar, Mahabaleshwar V. Hegde, Yogesh S. Badhe |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
hepatoprotective potential
Antioxidant Bilirubin medicine.medical_treatment lcsh:Analytical chemistry lcsh:RS1-441 Bioengineering Ether Pharmacology digestive system General Biochemistry Genetics and Molecular Biology lcsh:Pharmacy and materia medica chemistry.chemical_compound Hepatic damage n-Butanol parasitic diseases medicine flaxseed Liver damage General Pharmacology Toxicology and Pharmaceutics Alanine aminotransferase lcsh:QD71-142 Chemistry ether soluble phenolic components of n-butanol fraction digestive system diseases Antioxidant potential Biochemistry cardiovascular system Alkaline phosphatase Original Article |
| Zdroj: | Journal of Pharmacy & Bioallied Sciences Journal of Pharmacy and Bioallied Sciences, Vol 4, Iss 3, Pp 231-235 (2012) |
| ISSN: | 0975-7406 0976-4879 |
| Popis: | Objective: to investigate the hepatoprotective potential of ether insoluble phenolic components of n-butanol fraction (EPC-BF) of flaxseed against CCl 4 -induced liver damage in rats. Materials and Methods: Hepatotoxicity was induced to Wistar rats by administration of 0.2% CCl 4 in olive oil (8 mL/kg, i.p.) on the seventh day of treatment. Hepatoprotective potential of EPC-BF at doses, 250 and 500 mg/kg, p.o. was assessed through biochemical and histological parameters. Results: EPC-BF and silymarin pretreated animal groups showed significantly decreased activities of Aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), and level of total bilirubin, elevated by CCl 4 intoxication. Hepatic lipid peroxidation elevated by CCl 4 intoxication were also found to be alleviated at almost normal level in the EPC-BF and silymarin pretreated groups. Histological studies supported the biochemical findings and treatment of EPC-BF at doses 250 and 500 mg/kg, p.o. was found to be effective in restoring CCl 4 -induced hepatic damage. However, EPC-BF did not show dose-dependent hepatoprotective potential. EPC-BF depicted maximum protection against CCl 4 -induced hepatic damage at lower dose 250 mg/kg than higher dose (500 mg/ kg). Conclusion: EPC-BF possesses the significant hepatoprotective activity against CCl 4 induced liver damage, which could be mediated through increase in antioxidant defenses. |
| Databáze: | OpenAIRE |
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