Impact of BRCA1/2 testing and disclosure of a positive test result on women affected and unaffected with breast or ovarian cancer
| Autor: | Nicoline Hoogerbrugge, U. Moog, Mariëlle S. van Roosmalen, Lia C.G. Verhoef, Peep F. M. Stalmeier, Josette E. H. M. Hoekstra-Weebers, W.A.J. van Daal, Jan C. Oosterwijk |
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| Přispěvatelé: | Faculteit Medische Wetenschappen/UMCG, Science in Healthy Ageing & healthcaRE (SHARE), Damage and Repair in Cancer Development and Cancer Treatment (DARE), Targeted Gynaecologic Oncology (TARGON), Health Psychology Research (HPR) |
| Jazyk: | angličtina |
| Rok vydání: | 2004 |
| Předmět: |
Adult
medicine.medical_specialty Genes BRCA2 Genes BRCA1 Breast Neoplasms MUTATION CARRIERS DECISION-MAKING SUSCEPTIBILITY decision making FAMILIES genetic testing Breast cancer DISTRESS well-being medicine Humans Genetics (clinical) SCALE Ovarian Neoplasms RISK Univariate analysis Cancer prevention business.industry Obstetrics Repeated measures design Cancer BRCA1/2 mutation Middle Aged medicine.disease Distress Treatment Outcome Anxiety Female medicine.symptom business PSYCHOLOGICAL IMPACT Blood sampling |
| Zdroj: | American Journal of Medical Genetics. Part A, 124A(4), 346-355. Wiley |
| ISSN: | 1552-4825 |
| DOI: | 10.1002/ajmg.a.20374 |
| Popis: | To evaluate the impact of BRCA1/2 testing and disclosure of a positive test result on women affected and unaffected with cancer. Longitudinal cohort study including women affected and unaffected with breast or ovarian cancer testing for a BRCA1/2 mutation. Data on well-being (anxiety, depression, cancer related distress, general health), treatment choice, and decision making about cancer prevention were collected at baseline (1 week after blood sampling; affected n = 192, unaffected n = 176) and at follow-up (2 weeks after disclosure of a positive test result; affected n = 23, unaffected, n = 66). Women affected and unaffected with breast or ovarian cancer were compared using univariate statistics. Change over time was examined using repeated measures analysis of variance. With respect to well-being, affected women scored worse at baseline. At follow-up, both affected and unaffected women experienced a decline in well-being, which tended to be stronger in affected women. Women diagnosed with cancer less than 1 year previously tended to report a worse well-being than those diagnosed longer ago. With respect to treatment choice, more affected women intended to obtain prophylactic surgery and valued it higher at both time points. With respect to decision making, affected women had a lower preference for participation in decision making at baseline; no differences were found at follow-up. At follow-up, both affected and unaffected women showed an increase in strength of treatment preference and a decrease in decision uncertainty. Disclosure of a positive test result had a negative impact on well-being. Affected women, especially those who have been recently diagnosed with cancer, experienced the worst well-being and could benefit from psychosocial support. (C) 2003 Wiley-Liss, Inc. |
| Databáze: | OpenAIRE |
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