Expansion of regulatory T cells in aged mice following influenza infection
| Autor: | Jiu Jiang, Donna M. Murasko, Yolanda Williams-Bey |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Antigens
Differentiation T-Lymphocyte Senescence Aging Time Factors Ratón Cell Mice Transgenic chemical and pharmacologic phenomena Spleen CD8-Positive T-Lymphocytes Biology T-Lymphocytes Regulatory Article Mice Immune system Orthomyxoviridae Infections Antigens CD medicine Animals Cytotoxic T cell Lectins C-Type Mice Inbred BALB C CD69 Interleukin-2 Receptor alpha Subunit Forkhead Transcription Factors hemic and immune systems T lymphocyte Mice Inbred C57BL Disease Models Animal Phenotype medicine.anatomical_structure Immunology Developmental Biology |
| Zdroj: | Mechanisms of Ageing and Development. 132:163-170 |
| ISSN: | 0047-6374 |
| DOI: | 10.1016/j.mad.2011.03.001 |
| Popis: | While it has been established that Treg cells can down-modulate an immune response, no study has addressed if the observed increase in Treg cells in aged mice is related to the decreased and delayed specific CD8 T cell responses seen following primary influenza infection. In this study, phenotypic characteristics and function of Treg cells were analyzed in young (4–6 months) and aged (18–22 months) mice prior to and during the course of primary influenza infection. Upon infection, aged, but not young, mice have a significant expansion of Treg cells. In addition, Treg cells of aged mice demonstrate both a higher percentage and higher expression per cell of CD69 both at baseline and during infection compared to young mice. However, Treg cells isolated from young and aged mice comparably suppress CD8 T cells and suppression is dose dependent. These results suggest that the increase in the percentage of Treg cells in aged mice may contribute to the diminished CD8 T cell response to primary influenza infection. |
| Databáze: | OpenAIRE |
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