Effects of acute and chronic treatment with trazodone, an antidepressant, on the sleep-wake activity in rats
| Autor: | A Erdos, G. Rubicsek, P. Alföldi, Z. Lelkes, Ferenc Obál, G. Benedek |
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| Rok vydání: | 1994 |
| Předmět: |
Male
medicine.medical_specialty Time Factors medicine.medical_treatment Sleep wake Pharmacology Serotonergic Internal medicine medicine Animals Spectral analysis Wakefulness Saline Analysis of Variance Dose-Response Relationship Drug business.industry Trazodone Electroencephalography Sleep in non-human animals Rats Endocrinology Antidepressant Sleep Stages Serotonin Sleep business medicine.drug |
| Zdroj: | Pharmacological Research. 30:105-115 |
| ISSN: | 1043-6618 |
| DOI: | 10.1016/1043-6618(94)80002-2 |
| Popis: | Rats were treated with trazodone (2.5 or 10 mg kg −1 ) twice a day (at light and dark onset) for 11 days, after chronic injection of physiological saline. The sleep-wake activity was recorded for 24 h on the baseline day (saline), on trazodone days 1, 5 and 11, and also on day 12, when physiological saline was injected age (withdrawal day). Trazodone administration increased non-REM sleep. The enhancement of non-REM sleep was dose-related and more pronounced during the dark cycle. The promotion of non-REM sleep was enhanced during the chronic treatment. There were no consistent changes in REM sleep. Spectral analysis of the EEG revealed an increase in slow-wave activity after administration of the high dose (10 mg kg −1 ) of the drug. It is concluded that trazodone, a clinically effective antidepressant, has a non-REM sleep-promoting effect. It is speculated that the promotion of sleep by trazodone may be mediated by serotonergic mechanisms. |
| Databáze: | OpenAIRE |
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