Plasma kisspeptin levels in boys with hypogonadotropic delayed puberty
| Autor: | Elena Vasilieva, Igor A. Kelmanson, Irina L. Nikitina, Elena N. Grineva, Yulia N. Yukhlina, Irena Nagornaya |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
Delayed puberty medicine.medical_specialty Adolescent Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism Stimulation Gonadotropin-Releasing Hormone 03 medical and health sciences 0302 clinical medicine Endocrinology Kisspeptin Internal medicine Internal Medicine medicine Humans Child Puberty Delayed Kisspeptins Normal puberty business.industry Significant difference Plasma levels Triptorelin Case-Control Studies 030220 oncology & carcinogenesis medicine.symptom business medicine.drug Hormone |
| Zdroj: | Minerva Endocrinologica. 45 |
| ISSN: | 1827-1634 0391-1977 |
| DOI: | 10.23736/s0391-1977.20.03101-6 |
| Popis: | BACKGROUND In hypogonadotropic forms of delayed puberty (DP), hypophyseal follicle-stimulating (FSH) and luteinizing (LH) hormones, normally released with GnRH stimulation, are detected low. Since kisspeptin (KP) is a strong stimulant of GnRH neurons, it is considered to have a role in DP etiology. It may be hypothesized that abnormal plasma levels of KP are indicative of DP. The study aimed at evaluation and comparison of plasma KP levels in boys of pre-pubertal age, with normal puberty and diagnosed primary hypogonadotropic forms of DP. METHODS The study comprised 22 boys with verified hypogonadotropic DP (age 14-17 years), 25 boys with normal puberty (age 14-17 years), and 28 pre-pubertal boys (age 6-9 years). Triprorelin stimulation test was performed in DP patients. Plasma KP values were compared between three groups. RESULTS Statistically significant difference was found for the overall distribution of the plasma KP values across different groups (Kruskal-Wallis H=21.95, P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|