Dose schedules in bleomycin treatment
| Autor: | Svend Juul Jørgensen |
|---|---|
| Rok vydání: | 1972 |
| Předmět: |
Male
Schedule medicine.medical_specialty medicine.medical_treatment Bleomycin Injections Mice Neoplasms Muscle Tissue chemistry.chemical_compound Therapeutic index Carcinoma medicine Animals Transplantation Homologous Neoplasm Chemotherapy Antibiotics Antineoplastic business.industry Therapeutic effect Neoplasms Experimental General Medicine medicine.disease Surgery Liver chemistry Anesthesia Toxicity Female Chemical and Drug Induced Liver Injury business Neoplasm Transplantation Methylcholanthrene |
| Zdroj: | European Journal of Cancer (1965). 8:93-97 |
| ISSN: | 0014-2964 |
| DOI: | 10.1016/0014-2964(72)90088-6 |
| Popis: | Three different dose schedules have been tested in bleomycin treatment of a methylcholantrene induced dermoid carcinoma transplanted intramuscularly in mice. The reduction of tumour growth was used as a criteria for the therapeutic effect. 1. Schedule 1 : Daily injection for 8 days. 2. Schedule 2 : Injection twice a week for 3 weeks. 3. Schedule 3 : Cyclic treatment, i.e. 6 injections/ 48 hr/week in 3 weeks. Schedules 1 and 2 gave identical results concerning therapeutic effect and toxicity. Dose schedule 3 gave a slight reduction of the therapeutic effect and a marked reduction of the toxicity as compared to schedule 1 and 2 . The result is a better therapeutic index for cyclic treatment. |
| Databáze: | OpenAIRE |
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