Added value today of hormonal measurements in ovarian stimulation in gonadotropin-releasing hormone antagonist treatment cycle
| Autor: | Christophe Blockeel, Biljana Popovic-Todorovic, Annalisa Racca |
|---|---|
| Přispěvatelé: | Centre for Reproductive Medicine - Gynaecology, Surgical clinical sciences, Reproduction and Genetics |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Hormone Antagonists/therapeutic use medicine.medical_specialty medicine.drug_class Ovarian hyperstimulation syndrome Stimulation Hormone antagonist Gonadotropin-releasing hormone antagonist Gonadotropin-Releasing Hormone Ovarian Hyperstimulation Syndrome Estradiol/blood 03 medical and health sciences Hormone Antagonists Gonadotropin-Releasing Hormone/antagonists & inhibitors 0302 clinical medicine Ovarian Follicle Ovulation Induction Progesterone/blood Internal medicine Obstetrics and Gynaecology Ovarian Follicle/drug effects medicine Progesterone elevation Humans Endocrine system Progesterone Monitoring Physiologic Ovarian Hyperstimulation Syndrome/blood 030219 obstetrics & reproductive medicine Estradiol business.industry Obstetrics and Gynecology Luteinizing Hormone Ovulation Induction/methods medicine.disease Ovarian stimulation monitoring 030104 developmental biology Endocrinology Basal hormonal values Luteinizing Hormone/blood Female Luteinizing hormone business Embryo quality Hormone |
| Zdroj: | Current Opinion in Obstetrics & Gynecology. 30:145-150 |
| ISSN: | 1473-656X 1040-872X |
| DOI: | 10.1097/gco.0000000000000459 |
| Popis: | PURPOSE OF REVIEW: Traditional approach of ovarian stimulation monitoring for in-vitro fertilization involves transvaginal sonography and serum estradiol measurements. Accumulating evidence has shown that hormonal evaluations during ovarian stimulation allow individual cycle optimization, moving away from only predicting the risk of ovarian hyperstimulation syndrome, but in addition assessing the impact of ovarian stimulation on endometrial receptivity, quality of oocytes, and subsequently embryos. The purpose of this review is to discuss the relevance and added value of hormonal monitoring during ovarian stimulation in gonadotropin-releasing hormone antagonist cycles where most of the advances have occurred. RECENT FINDINGS: Basal hormonal status, particularly estradiol, progesterone, and luteinizing hormone are instrumental in prediction of the patients with poor prognosis. Estradiol levels on the day of trigger are less sensitive in predicting ovarian hyperstimulation syndrome then the number of folliclesmore than 11 mm in diameter. Progesterone elevation on the day of trigger is associated with lower pregnancy rates. The gold standard treatment for progesterone elevation is to adopt a freeze-all strategy when the threshold of 1.50 ng/ml is exceeded. The effect of progesterone elevation on embryo quality remains to be confirmed by more trials. SUMMARY: Endocrine monitoring during ovarian stimulation allows fine-tuning of the physiology of the stimulated cycle and thereby increases the chances of successful treatment outcome. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|