Reversal of neuromuscular effects of adenosine by specific adenosine A1-receptor antagonist in live rats
| Autor: | E. Sylvester Vizi, Shinjiro Shono, Kazuo Higa, Mari Iihoshi, Hideyuki Higuchi, Keiichi Nitahara |
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| Rok vydání: | 2005 |
| Předmět: |
Agonist
Male medicine.medical_specialty Adenosine Agonist-antagonist medicine.drug_class Neuromuscular Junction Adenosine A1 Receptor Antagonists Synaptic Transmission Neuromuscular junction Rats Sprague-Dawley Adenosine A1 receptor Internal medicine medicine Animals Drug Interactions Vecuronium Bromide Chemistry Receptor Adenosine A1 General Neuroscience Antagonist Drug Synergism General Medicine Neuromuscular Blocking Agents Adenosine receptor Sciatic Nerve Adenosine A1 Receptor Agonists Rats Endocrinology medicine.anatomical_structure Xanthines medicine.drug Neuromuscular Nondepolarizing Agents |
| Zdroj: | The International journal of neuroscience. 115(3) |
| ISSN: | 0020-7454 |
| Popis: | Intravenous adenosine in-vivo was shown to potentiate the effects of non-depolarizing neuromuscular blocking agents. This study aimed to determine whether adenosine A1-receptors mediated this potentiation. The authors investigated the effects of intravenous adenosine, N6-cyclopentyladenosine, specific A1-receptor agonist, and 8-cyclopentyl-1,3-dipropylxanthine, specific A1-receptor antagonist, on neuromuscular block by vecuronium, in in-vivo rat sciatic nerve-tibialis anterior preparations. In the presence of 50% steady state block by vecuronium, adenosine, and N6-cyclopentyladenosine caused similar degree of depressions of twitch tension. Twitch tension returned to its pre-injection value more rapidly when 8-cyclopentyl-1,3-dipropylxanthine was given at the maximal block than when it was allowed to recover spontaneously. It was concluded that in in-vivo adenosine potentiated the neuromuscular effects of vecuronium through adenosine A1-receptors in rats. |
| Databáze: | OpenAIRE |
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