Quaternary ammonium salts and their antimicrobial potential: targets or nonspecific interactions?
| Autor: | Maximilian Tischer, Gabriele Pradel, Knut Ohlsen, Ulrike Holzgrabe |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Plasmodium
medicine.drug_class Disinfectant Microbial Sensitivity Tests Biochemistry chemistry.chemical_compound Structure-Activity Relationship Antiseptic Anti-Infective Agents Drug Discovery medicine Structure–activity relationship Organic chemistry Animals Humans Ammonium General Pharmacology Toxicology and Pharmaceutics Pharmacology Dequalinium Bacteria Organic Chemistry Bacterial Infections Antimicrobial Ammonium compounds Malaria Quaternary Ammonium Compounds chemistry Dequalinium chloride Molecular Medicine Salts |
| Zdroj: | ChemMedChem. 7(1) |
| ISSN: | 1860-7187 |
| Popis: | For more than 50 years dequalinium chloride has been used successfully as an antiseptic drug and disinfectant, particularly for clinical purposes. Given the success of dequalinium chloride, several series of mono- and bisquaternary ammonium compounds have been designed and reported to have improved antimicrobial activity. Furthermore, many of them exhibit high activity against mycobacteria and protozoa, especially against plasmodia. This review discusses the structure-activity relationships and the modes of action of the various series of (bis)quaternary ammonium compounds. |
| Databáze: | OpenAIRE |
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