The Vessels-Bone Axis: Iliac Artery Calcifications, Vertebral Fractures and Vitamin K from VIKI Study
| Autor: | Stefania Sella, Raffaele De Caterina, Enrico Schileo, Mario Plebani, Gaetano La Manna, Maurizio Gallieni, Lorenzo Gasperoni, Piergiorgio Messa, Giovanni Tripepi, Giorgio Iervasi, Markus Ketteler, Maria Luisa Brandi, Andrea Aghi, Cristina Politi, Serge Ferrari, Laura Cosmai, Giuseppe Cianciolo, Martina Zaninotto, Sandro Giannini, Maria Fusaro, Maria Cristina Mereu, Maura Ravera, Roberto Vettor, Luisella Cianferotti, Fulvia Taddei, Thomas L. Nickolas |
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| Přispěvatelé: | Fusaro M., Tripepi G., Plebani M., Politi C., Aghi A., Taddei F., Schileo E., Zaninotto M., La Manna G., Cianciolo G., Gallieni M., Cosmai L., Messa P., Ravera M., Nickolas T.L., Ferrari S., Ketteler M., Iervasi G., Mereu M.C., Vettor R., Giannini S., Gasperoni L., Sella S., Brandi M.L., Cianferotti L., Caterina R.D. |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Vitamin
Male medicine.medical_specialty Logistic Model medicine.medical_treatment Population Triglyceride Gastroenterology Iliac Artery Bone and Bones Article metabolic syndrome vitamin K chemistry.chemical_compound Internal medicine medicine Humans TX341-641 Aorta Abdominal Risk factor education Prospective cohort study Vascular Calcification Triglycerides Aged education.field_of_study Nutrition and Dietetics Spinal Fracture business.industry Nutrition. Foods and food supply Vitamin K2 Vitamin K 2 Middle Aged medicine.disease Epidemiology Metabolic syndrome Peripheral vascular disease Vitamin K Logistic Models chemistry peripheral vascular disease Spinal Fractures Female epidemiology Hemodialysis business Bone and Bone Human Food Science Kidney disease Calcification |
| Zdroj: | Nutrients, Vol 13, Iss 3567, p 3567 (2021) Nutrients Volume 13 Issue 10 |
| ISSN: | 2072-6643 |
| Popis: | Vascular calcification and fragility fractures are associated with high morbidity and mortality, especially in end-stage renal disease. We evaluated the relationship of iliac arteries calcifications (IACs) and abdominal aortic calcifications (AACs) with the risk for vertebral fractures (VFs) in hemodialysis patients. The VIKI study was a multicenter cross-sectional study involving 387 hemodialysis patients. The biochemical data included bone health markers, such as vitamin K levels, vitamin K-dependent proteins, vitamin 25(OH)D, alkaline phosphatase, parathormone, calcium, and phosphate. VF, IACs and AACs was determined through standardized spine radiograms. VF was defined as > 20% reduction of vertebral body height, and VC were quantified by measuring the length of calcium deposits along the arteries. The prevalence of IACs and AACs were 56.1% and 80.6%, respectively. After adjusting for confounding variables, the presence of IACs was associated with 73% higher odds of VF (p = 0.028), whereas we found no association (p = 0.294) for AACs. IACs were associated with VF irrespective of calcification severity. Patients with IACs had lower levels of vitamin K2 and menaquinone 7 (0.99 vs. 1.15 ng/mL p = 0.003), and this deficiency became greater with adjustment for triglycerides (0.57 vs. 0.87 ng/mL p < 0.001). IACs, regardless of their extent, are a clinically relevant risk factor for VFs. The association is enhanced by adjusting for vitamin K, a main player in bone and vascular health. To our knowledge these results are the first in the literature. Prospective studies are needed to confirm these findings both in chronic kidney disease and in the general population. |
| Databáze: | OpenAIRE |
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