CT findings predict survival of patients with peripheral T cell lymphoma: a preliminary study
| Autor: | Jianbang Lin, Sen Jiang, Wenbin Yang, Yang-Kang Li |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
R895-920 Disease Logistic regression 030218 nuclear medicine & medical imaging peripheral t cell lymphoma Medical physics. Medical radiology. Nuclear medicine 0302 clinical medicine Duodenal Neoplasms Antineoplastic Combined Chemotherapy Protocols Anaplastic Lymphoma Kinase Child Lymph node Aged 80 and over Univariate analysis Middle Aged medicine.anatomical_structure Treatment Outcome Oncology Vincristine 030220 oncology & carcinogenesis Area Under Curve Female Radiology medicine.symptom Paranasal Sinus Neoplasms Research Article Adult medicine.medical_specialty Adolescent lymphoma Mediastinal Neoplasms Lesion 03 medical and health sciences Necrosis Young Adult Multidetector Computed Tomography medicine Humans Radiology Nuclear Medicine and imaging Neoplasm Invasiveness Cyclophosphamide Aged Retrospective Studies business.industry Univariate Lymphoma T-Cell Peripheral computed tomography medicine.disease Peripheral T-cell lymphoma Lymphoma Logistic Models ROC Curve Doxorubicin Prednisone prognosis business Tomography Spiral Computed |
| Zdroj: | Radiology and Oncology, Vol 53, Iss 1, Pp 31-38 (2019) Radiology and Oncology |
| ISSN: | 1581-3207 |
| Popis: | Background Peripheral T-cell lymphoma (PTCL) is an uncommon disease with poor clinical outcomes. Radiological reports on the survival of patients with PTCL are scarce. The purpose of this study is to investigate the prognostic value of CT findings to predict clinical outcomes in fifty-one patients with histologically proven PTCL. Patients and methods The clinical data and CT images of all patients were retrospectively reviewed. CT features including number of involvement sites, lesion size, shape, margin, density, peritumoral invasion, intratumoral necrosis, lymph node involvement, and degree of contrast enhancement were evaluated. Univariate and multiple logistic regression analysis were used to determine the association between the clinical outcome and radiologic factors. Results Multiple site involvement, an ill-defined margin with peritumoral invasion, inhomogeneous density, and intratumoral necrosis were found to be associated with poor outcomes in univariate analysis (P < 0.05). An ill-defined margin with peritumoral invasion, was identified as an independent risk sign by further multivariate logistic regression analysis (P < 0.05). The area under the ROC curve of this CT feature was 0.745 (P < 0.05). Conclusions An ill-defined margin with peritumoral invasion was a valuable prognostic factor to predict the worse clinical outcomes in patients with PTCL. |
| Databáze: | OpenAIRE |
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