Compressive properties of fibrous repair tissue compared to nucleus and annulus
| Autor: | Glenn R. Buttermann, Andrew L. Freeman, Brian P. Beaubien, Willie E. Rochefort |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Biomedical Engineering Biophysics Aggregate modulus Young Adult Lumbar medicine Humans Orthopedics and Sports Medicine Intervertebral Disc Aged Wound Healing Lumbar Vertebrae biology Viscosity Chemistry Rehabilitation Histology Anatomy Middle Aged musculoskeletal system Elasticity Biomechanical Phenomena medicine.anatomical_structure Proteoglycan biology.protein Female Proteoglycans Collagen Stress Mechanical Implant Swelling medicine.symptom Wound healing Nucleus |
| Zdroj: | Journal of Biomechanics. 46:1714-1721 |
| ISSN: | 0021-9290 |
| DOI: | 10.1016/j.jbiomech.2013.03.034 |
| Popis: | The wound healing process includes filling the void between implant and tissue edges by collagenous connective repair tissue. This fibrous repair tissue may load share or stabilize implants such as spinal disc replacements. The objective of this study was the biomechanical characterization of human fibrous tissue compared to annulus fibrosus and nucleus pulposus. Human lumbar discs (10 nucleus and annulus) and 10 lumbar deep wound fibrous tissue specimens were sectioned into 12mm diameter×6mm high cylindrical samples. Confined compression testing, after 2h swelling at 0.11MPa, was performed at 5%, 10% and 15% strain over 3.5h. Unconfined dynamic testing (2-0.001Hz) was performed at 5-15% strain. Semi-quantitative histology estimated the proportion of proteoglycan to collagen. Fibrous tissue exhibited a decrease in height during the swelling period whereas annulus and nucleus tissues did not. The aggregate modulus was significantly less for fibrous tissue (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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