Liver-specific metabolomics characterizes the hepatoprotective effect of saponin-enriched Celosiae Semen extract on mice with nonalcoholic fatty liver disease
Autor: | Hui-Jun Li, Dan Liang, Ping Li, Feng-Jie Liu, Lan-Yun Miao |
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Rok vydání: | 2018 |
Předmět: |
0301 basic medicine
Saponin Medicine (miscellaneous) Semen Pharmacology Biology 03 medical and health sciences 0302 clinical medicine Metabolomics Nonalcoholic fatty liver disease medicine GC–MS TX341-641 chemistry.chemical_classification Nutrition and Dietetics Nutrition. Foods and food supply Liver-specific metabolomics Lipid metabolism medicine.disease Celosiae Semen 030104 developmental biology Hepatoprotection chemistry Phytochemical 030220 oncology & carcinogenesis Gas chromatography–mass spectrometry Food Science |
Zdroj: | Journal of Functional Foods, Vol 42, Iss, Pp 185-194 (2018) |
ISSN: | 1756-4646 |
DOI: | 10.1016/j.jff.2017.12.069 |
Popis: | Celosiae Semen, derived from the seeds of Celosia argentea L., has a long history of therapeutic uses for liver diseases in China and Japan. Phytochemical researches revealed a series of saponins from Celosiae Semen, which showed a variety of important pharmacological properties such as anti-hyperlipidemia and hepatoprotection. However, the exact protection mechanism is still looking forward to further elucidation. In present study, a liver-specific metabolomics approach based on gas chromatography-mass spectrometry (GC–MS) was applied to investigate the hepatoprotective effect of saponin-enriched Celosiae Semen extract (SECSE) under high-fat diet (HFD) induced nonalcoholic fatty liver disease (NAFLD). Orthogonal partial least squares discriminant analysis (OPLS-DA) was used to identify different metabolic profiles of liver from C57BL/6 mice. At the meantime, serum biochemical analysis and liver histopathological examination were performed. The results suggested that SECSE has effective protection to NAFLD, which is associated with energy metabolism, amino acid metabolism and lipid metabolism. |
Databáze: | OpenAIRE |
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