Antifungal action of α-pinene against Candida spp. isolated from patients with otomycosis and effects of its association with boric acid
| Autor: | Daniele de Figueredo Silva, Edeltrudes de Oliveira Lima, Francisco Patricio de Andrade Júnior, Paula Mariane Silva Sousa, Laísa Vilar Cordeiro, Pedro Thiago Ramalho de Figueiredo, Jefferson Nóbrega |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Antifungal
Pinene 010405 organic chemistry Chemistry medicine.drug_class Organic Chemistry Otomycosis Plant Science Antimicrobial medicine.disease 01 natural sciences Biochemistry Blastoconidium 0104 chemical sciences Analytical Chemistry Microbiology Fungicide Boric acid 010404 medicinal & biomolecular chemistry chemistry.chemical_compound Fungal Structures medicine |
| Zdroj: | Natural Product Research. 35:6190-6193 |
| ISSN: | 1478-6427 1478-6419 |
| DOI: | 10.1080/14786419.2020.1837803 |
| Popis: | The genus Candida is one of the main causes of otomycosis. The growing index of fungal strains resistant to antifungals makes necessary the search for new agents and α-pinene is a phytoconstituent present in plants with remarkable antimicrobial activity, which becomes an interesting object of study. Thus, the objective of this research was to evaluate the antifungal activity of α-pinene against Candida species isolated from otomycosis, determining the Minimum Inhibitory and Fungicide Concentrations, micromorphological analysis and verifying the effects of the association with boric acid. α-pinene showed significant antifungal activity, with greater inhibitory activity against C. parapsilosis, fungicidal action and proved to be effective in inhibiting fungal structures, such as pseudo-hyphae and promoting a marked decrease in blastoconidia. The combination of α-pinene with boric acid produced additive effects that may be interesting for use in clinical practice. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|