Validation of an optimized SPM procedure for FDG-PET in dementia diagnosis in a clinical setting

Autor: Perani D, Della Rosa PA, Cerami C, Gallivanone F, Fallanca F, Vanoli EG, Panzacchi A, Nobili F, Pappatà S, Marcone A, Garibotto V, CASTIGLIONI I, Magnani G, Cappa SF, Gianolli L, Drzezga A, Perneczky R, Didic M, Guedj E, Van Berckel BN, Ossenkoppele R, Morbelli S, Frisoni G, Caroli A
Přispěvatelé: Radiology and nuclear medicine, NCA - Brain imaging technology, NCA - neurodegeneration, Perani, D, Della Rosa, P, Cerami, C, Gallivanone, F, Fallanca, F, Vanoli, E, Panzacchi, A, Nobili, F, Pappatà, S, Marcone, A, Garibotto, V, Castiglioni, I, Magnani, G, Cappa, S, Gianolli, L, Drzezga, A, Perneczky, R, Didic, M, Guedj, E, Van Berckel, B, Ossenkoppele, R, Morbelli, S, Frisoni, G, Caroli, A, Della Rosa, Pasquale Anthony, Cerami, Chiara, Gallivanone, Francesca, Fallanca, Federico, Vanoli, Emilia Giovanna, Panzacchi, Andrea, Nobili, Flavio, Pappata, Sabina, Marcone, Alessandra, Garibotto, Valentina, Castiglioni, Isabella, Magnani, Giuseppe, Cappa, Stefano, Gianolli, Luigi
Jazyk: angličtina
Rok vydání: 2014
Předmět:
NATIONAL INSTITUTE
Male
MILD COGNITIVE IMPAIRMENT
Data Interpretation
Neurology
Statistical Parametrical Mapping
GUIDELINES
lcsh:RC346-429
DISEASE
RECOMMENDATIONS
030218 nuclear medicine & medical imaging
Computer-Assisted
0302 clinical medicine
pet
Dementia diagnosis
Nuclear Medicine and Imaging
Diagnosis
80 and over
F-18-FDG PET
Diagnosis
Computer-Assisted
10. No inequality
Aged
80 and over
FDG-PET imaging
Statistical parametrical mapping
Voxel-based analysis
Aged
Brain
Data Interpretation
Statistical
Female
Fluorodeoxyglucose F18
Humans
Middle Aged
Neurodegenerative Diseases
Positron-Emission Tomography
Sensitivity and Specificity
Neurology (clinical)
Radiology
Nuclear Medicine and Imaging
Cognitive Neuroscience
Medicine (all)
medicine.diagnostic_test
EADC-PET Consortium
GLUCOSE-METABOLISM
ALZHEIMERS ASSOCIATION WORKGROUPS
Statistical
LEWY BODIES
3. Good health
Positron emission tomography
lcsh:R858-859.7
Radiology
Psychology
Life Sciences & Biomedicine
medicine.medical_specialty
Neuroimaging
Neurodegenerative Diseases/diagnosis
lcsh:Computer applications to medicine. Medical informatics
ddc:616.0757
Article
03 medical and health sciences
mental disorders
medicine
Dementia
Brain/metabolism
Radiology
Nuclear Medicine and imaging
lcsh:Neurology. Diseases of the nervous system
Science & Technology
business.industry
fungi
Gold standard (test)
FRONTOTEMPORAL DEMENTIA
medicine.disease
Positron-Emission Tomography/methods
Clinical diagnosis
Neurosciences & Neurology
Differential diagnosis
Nuclear medicine
business
030217 neurology & neurosurgery
Zdroj: NeuroImage: Clinical, Vol. 6 (2014) pp. 445-54
NeuroImage : Clinical
EADC-PET Consortium 2014, ' Validation of an optimized SPM procedure for FDG-PET in dementia diagnosis in a clinical setting ', NeuroImage: Clinical, vol. 6, pp. 445-454 . https://doi.org/10.1016/j.nicl.2014.10.009
NeuroImage: Clinical 6 (2014): 445–454. doi:10.1016/j.nicl.2014.10.009
info:cnr-pdr/source/autori:Daniela Perani a,b,c,d 1, Pasquale Anthony Della Rosa d 1, Chiara Ceramia e 1, Francesca Gallivanone d, Federico Fallanca c, Emilia Giovanna Vanoli c, Andrea Panzacchi c, Flavio Nobili f, Sabina Pappatà g, Alessandra Marcone f, Valentina Garibotto h, Isabella Castiglioni d, Giuseppe Magnani i, Stefano F. Cappa e,j, Luigi Gianolli c, EADC-PET Consortium 2/titolo:Validation of an optimized SPM procedure for FDG-PET in dementia diagnosis in a clinical setting/doi:10.1016%2Fj.nicl.2014.10.009/rivista:NeuroImage: Clinical/anno:2014/pagina_da:445/pagina_a:454/intervallo_pagine:445–454/volume:6
NeuroImage: Clinical, 6, 445-454. Elsevier BV
NeuroImage: Clinical, Vol 6, Iss C, Pp 445-454 (2014)
ISSN: 2213-1582
Popis: Diagnostic accuracy in FDG-PET imaging highly depends on the operating procedures. In this clinical study on dementia, we compared the diagnostic accuracy at a single-subject level of a) Clinical Scenarios, b) Standard FDG Images and c) Statistical Parametrical (SPM) Maps generated via a new optimized SPM procedure. We evaluated the added value of FDG-PET, either Standard FDG Images or SPM Maps, to Clinical Scenarios. In 88 patients with neurodegenerative diseases (Alzheimer's Disease—AD, Frontotemporal Lobar Degeneration—FTLD, Dementia with Lewy bodies—DLB and Mild Cognitive Impairment—MCI), 9 neuroimaging experts made a forced diagnostic decision on the basis of the evaluation of the three types of information. There was also the possibility of a decision of normality on the FDG-PET images. The clinical diagnosis confirmed at a long-term follow-up was used as the gold standard. SPM Maps showed higher sensitivity and specificity (96% and 84%), and better diagnostic positive (6.8) and negative (0.05) likelihood ratios compared to Clinical Scenarios and Standard FDG Images. SPM Maps increased diagnostic accuracy for differential diagnosis (AD vs. FTD; beta 1.414, p = 0.019). The AUC of the ROC curve was 0.67 for SPM Maps, 0.57 for Clinical Scenarios and 0.50 for Standard FDG Images. In the MCI group, SPM Maps showed the highest predictive prognostic value (mean LOC = 2.46), by identifying either normal brain metabolism (exclusionary role) or hypometabolic patterns typical of different neurodegenerative conditions.
Highlights • Brain FDG-PET was evaluated with a new optimized SPM procedure in dementias. • We compared the diagnostic accuracy of clinical information, visual and SPM FDG-PET. • SPM had the best sensitivity (96%), specificity (84%) and positive and negative LR. • In an MCI subgroup, SPM had the highest predictive prognostic value.
Databáze: OpenAIRE
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