Anterograde transport of HSV-1 and HSV-2 in the visual system
| Autor: | Arden Wander, John H. McLean, Michael N. Lehman, H. Curt Bubel, David I. Bernstein, Robert B. Norgren |
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| Rok vydání: | 1992 |
| Předmět: |
Male
Cholera Toxin viruses Retinitis HSL and HSV Biology Visual system medicine.disease_cause Lateral geniculate nucleus Retinal ganglion Cricetinae medicine Animals Simplexvirus Visual Pathways Horseradish Peroxidase Mesocricetus General Neuroscience Superior colliculus Brain medicine.disease Virology Immunohistochemistry Herpes simplex virus Axoplasmic transport Keratitis Herpetic Neuroscience Neuroglia |
| Zdroj: | Brain research bulletin. 28(3) |
| ISSN: | 0361-9230 |
| Popis: | The anterograde spread of herpesvirus in the visual system subsequent to retinitis has been observed clinically. We compared the ability of two well-studied Herpes simplex virus (HSV) strains to be transported in the anterograde direction in the hamster visual system: strain McIntyre, representing HSV-1, and strain 186, representing HSV-2. Intravitreal injection of HSV-2 labeled more retinorecipient neurons than did HSV-1, suggesting important type differences in the ability of HSV to infect retinorecipient neurons after intravitreal injection. The most likely explanation for our results is that HSV-2 is more efficiently adsorbed than HSV-1 in the retinal ganglion cells. Our results also suggest that HSV may be useful as an anterograde transneuronal tracer for neuroanatomical studies of the visual system. |
| Databáze: | OpenAIRE |
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