Assessment of Vitronectin, Soluble Epithelial-Cadherin and TGF-β1 as a Serum Biomarker with Predictive Value for Endometrial and Ovarian Cancers
| Autor: | Aymelek Gönenç, Taylan Turan, Meral Torun, Funda Atalay |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
lcsh:RS1-441 Pharmaceutical Science Gastroenterology Metastasis lcsh:Pharmacy and materia medica Internal medicine medicine Clinical significance Vitronectin sE-cadherin TGF-ß1 biology Cadherin business.industry Endometrial cancer Cancer medicine.disease ovarian cancer endometrial cancer biology.protein Molecular Medicine Original Article Ovarian cancer business Transforming growth factor |
| Zdroj: | Turkish Journal of Pharmaceutical Sciences, Vol 14, Iss 2, Pp 141-147 (2017) Turkish Journal of Pharmaceutical Sciences |
| ISSN: | 2148-6247 1304-530X |
| DOI: | 10.4274/tjps.81994 |
| Popis: | Objectives: Extracellular matrix components, including vitronectin (VN), soluble epithelial-cadherin (sE-cadherin) and transforming growth factor-beta 1 (TGF-β1), play a key role in the invasion and metastasis of cancer. The objective of the study was to determine the clinical significance of serum levels of these molecules in patients with endometrial and ovarian cancers. Materials and Methods: Serum levels of VN, sE-cadherin and TGF-β1 in patients with endometrial (n=28) and ovarian cancers (n=40) and healthy controls (n=41) were measured by ELISA using commercial kits. Results: A significant difference was found in VN, sE-cadherin and TGF-β1 levels between patients and healthy controls (p |
| Databáze: | OpenAIRE |
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