Erratum: Rémy et al. Modelling the Impact of Chronic Cigarette Smoke Exposure in Obese Mice: Metabolic, Pulmonary, Intestinal, and Cardiac Issues. Nutrients 2020, 12, 827
| Autor: | Philippe Gosset, Corinne Grangette, Delphine Beury, Isabelle Wolowczuk, Gwenola Kervoaze, Léa Siegwald, Florence Pinet, Maggy Chwastyniak, David Hot, Jeanne Alard, Morgane Baron, Gaëlle Rémy, Ségolène Caboche, Emilie Dubois-Deruy, Muriel Pichavant |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Physiology Cardiomegaly Mice Nutrient Animals Homeostasis Humans Insulin Medicine TX341-641 Obesity Life Style Lung Obese Mice Nutrition and Dietetics Nutrition. Foods and food supply business.industry Microbiota Smoking Environmental Exposure Cigarette smoke exposure Disease Models Animal Glucose n/a Adipose Tissue Organ Specificity Cytokines Disease Susceptibility Erratum Energy Metabolism business Biomarkers Food Science |
| Zdroj: | Nutrients, Vol 13, Iss 3084, p 3084 (2021) Nutrients |
| ISSN: | 2072-6643 |
| Popis: | Unhealthy lifestyle choices, such as bad eating behaviors and cigarette smoking, have major detrimental impacts on health. However, the inter-relations between obesity and smoking are still not fully understood. We thus developed an experimental model of high-fat diet-fed obese C57BL/6 male mice chronically exposed to cigarette smoke. Our study evaluated for the first time the resulting effects of the combined exposure to unhealthy diet and cigarette smoke on several metabolic, pulmonary, intestinal, and cardiac parameters. We showed that the chronic exposure to cigarette smoke modified the pattern of body fat distribution in favor of the visceral depots in obese mice, impaired the respiratory function, triggered pulmonary inflammation and emphysema, and was associated with gut microbiota dysbiosis, cardiac hypertrophy and myocardial fibrosis. |
| Databáze: | OpenAIRE |
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