Carboplatin and vinorelbine in the treatment of advanced non-small-cell lung cancer: a multicenter phase II study
| Autor: | Renato Algeri, F. Pepi, Roberto Righi, Enrico Tucci, Michela Rinaldini, Paolo Ghezzi, Antonio Andrei, Carmine Santomaggio, Antonio Bellezza |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Oncology
Adult Male Cancer Research medicine.medical_specialty Lung Neoplasms medicine.medical_treatment Phases of clinical research Vinorelbine Vinblastine Carboplatin chemistry.chemical_compound Internal medicine Carcinoma Non-Small-Cell Lung Antineoplastic Combined Chemotherapy Protocols medicine Humans Lung cancer Survival analysis Aged Cisplatin Chemotherapy business.industry Middle Aged medicine.disease Survival Analysis Surgery chemistry Female business medicine.drug |
| Zdroj: | American journal of clinical oncology. 21(1) |
| ISSN: | 0277-3732 |
| Popis: | The aim of this study was to identify a chemotherapy combination that would be active and well tolerated for palliative treatment of advanced non-small-cell lung cancer (NSCLC). From February 1992 to December 1994, a total of 77 patients affected by stage-IIIB and stage-IV NSCLC were treated with carboplatin 350 mg/m2 on day 1 and vinorelbine 25 mg/m2 on days 1 and 8 of each cycle, with cycles repeated every 28 days. All patients were evaluable for response and toxicity. A total of 24 patients showed a partial response (31% response rate; 95% CI = 21-41%). The median duration of overall survival was 41 weeks (95% CI = 31-51), and the median time to disease progression was 34 weeks (95% CI = 25-43). The treatment was well tolerated: no grade-4 toxicity was observed. The carboplatin-vinorelbine combination deserves to considered as a valid alternative to regimens that include cisplatin for palliative treatment of advanced NSCLC. |
| Databáze: | OpenAIRE |
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