Postnatal intracerebroventricular administrations of NGF alter spatial memory in adulthood
| Autor: | Guido Vantini, Françoise Schenk, Catherine Brandner |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Male
Aging Escape latency Behavioral Neuroscience Escape Reaction Orientation Nerve Growth Factor Reaction Time medicine Animals Humans Rats Long-Evans Memory disorder Spatial representation Maze Learning Injections Intraventricular Cued speech Cognitive disorder Brain medicine.disease Recombinant Proteins Rats Nerve growth factor Animals Newborn Cholinergic Fibers Mental Recall Spatial learning Female Psychology Neuroscience After treatment |
| Zdroj: | Behavioural Brain Research. 111:165-173 |
| ISSN: | 0166-4328 |
| DOI: | 10.1016/s0166-4328(00)00153-4 |
| Popis: | The present work assessed the effects of intracerebroventricular injections (2×5 mg/2.5 ml) of recombined human nerve growth factor (rhNGF) at postnatal days 2 and 3 upon the development of spatial learning capacities in rats. The treated rats were trained at the age of 22 days to escape onto an invisible platform at a fixed position in space in a Morris navigation task. For half of the subjects, the training position was also cued, a procedure aimed at facilitating escape and reducing attention to the distant spatial cues. At the age of 2 months all the rats were retrained in the same task. Treatment effects were found in both immature and adult rats. The injection of NGF induced a slight alteration of the immature rats’ performance. In contrast, a marked impairment of spatial abilities was shown in the 2-month-old rats. The most consistent effects were a significant increase in the escape latency and a decrease bias towards the training platform area during probe trials. The reduction of spatial memory was particularly marked if the subjects had been trained in a cued condition. Taken together, these experiments reveal that an acute pharmacological treatment that leads to transient modifications during early development might induce a behavioural change long after treatment. Thus, the development and the maintenance of an accurate spatial representation are tightly related to the development of brain structures that could be altered by precocious NGF administrations. |
| Databáze: | OpenAIRE |
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