Regulation of gastric and pancreatic lipase secretion by CCK and cholinergic mechanisms in humans
| Autor: | C. Kreiss, B. Remy, J.B.M.J. Jansen, W. Schwizer, C. Mettraux, J. Borovicka, I. Douchet, R. Verger, M. Fried, K. Asal |
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| Rok vydání: | 1997 |
| Předmět: |
Adult
Male medicine.medical_specialty Duodenum Physiology Biology Nutrition secretion and motility Gastric Acid Pepsin Parasympathetic Nervous System Voeding secretie en motoriek Physiology (medical) Internal medicine Gastrins medicine Humans Gastric lipase Pancreas GeneralLiterature_REFERENCE(e.g. dictionaries encyclopedias glossaries) Cholecystokinin Gastrin Hepatology Gastric emptying Stomach digestive oral and skin physiology Gastroenterology Lipase Endocrinology Postprandial Gastric Emptying biology.protein Gastric acid Cholinergic Female hormones hormone substitutes and hormone antagonists |
| Zdroj: | American Journal of Physiology, 273, G374-G380 American Journal of Physiology, 273, G374-380 American Journal of Physiology, 273, 2, pp. G374-G380 American Journal of Physiology, 273, pp. G374-380 |
| ISSN: | 0002-9513 |
| Popis: | Gastric lipase (HGL) contributes significantly to fat digestion. However, little is known about its neurohormonal regulation in humans. We studied the role of CCK and cholinergic mechanisms in the postprandial regulation of HGL and pancreatic lipase (HPL) secretion in six healthy subjects. Gastric emptying of a mixed meal and outputs of HGL, pepsin, acid, and HPL were determined with a double-indicator technique. Three experiments were performed in random order: intravenous infusion of 1) placebo, 2) low-dose atropine (5 micrograms.kg-.h-1), and 3) the CCK-A receptor antagonist loxiglumide (22 mumol.kg-.h-1). Atropine decreased postprandial outputs of HGL, pepsin, gastric acid, and HPL (P < 0.03) while slowing gastric emptying (P < 0.05). Loxiglumide markedly increased the secretion of HGL, pepsin, and acid while distinctly reducing HPL outputs and accelerating gastric emptying (P < 0.03). Plasma CCK and gastrin levels increased during loxiglumide infusion (P < 0.03). Atropine enhanced gastrin but not CCK release. Postprandial HGL, pepsin, and acid secretion are under positive cholinergic but negative CCK control, whereas HPL is stimulated by cholinergic and CCK mechanisms. We conclude that CCK and cholinergic mechanisms have an important role in the coordination of HGL and HPL secretion to optimize digestion of dietary lipids in humans. |
| Databáze: | OpenAIRE |
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