No association between frequent apheresis donation and risk of fractures: a retrospective cohort analysis from S weden
| Autor: | R. Norda, Senthil K Vasan, Klaus Rostgaard, Donor Evaluation Study-III, Katrine Grau, Henrik Hjalgrim, Gustaf Edgren, Walter Bialkowski |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty Databases Factual Denmark Immunology Blood Donors 030204 cardiovascular system & hematology Rate ratio Article Bone remodeling Fractures Bone 03 medical and health sciences symbols.namesake 0302 clinical medicine Internal medicine medicine Humans Immunology and Allergy Registries Poisson regression Retrospective Studies Sweden business.industry Incidence Incidence (epidemiology) Retrospective cohort study Hematology Middle Aged Confidence interval Surgery Apheresis Donation Blood Component Removal symbols Female business Follow-Up Studies 030215 immunology |
| Zdroj: | Transfusion. 57:390-396 |
| ISSN: | 1537-2995 0041-1132 |
| DOI: | 10.1111/trf.13907 |
| Popis: | BACKGROUND Citrate anticoagulation during apheresis induces transient alterations in calcium homeostasis. It is unknown whether the repeated, transient alterations in calcium homeostasis experienced by repeated apheresis donors affects bone turnover to increase fracture risk. Our aim was to investigate the risk of osteoporotic and nonosteoporotic fracture among voluntary, frequent apheresis donors. STUDY DESIGN AND METHODS All apheresis donors were identified from the Scandinavian Donations and Transfusions database (SCANDAT2), which includes information on over 1.6 million blood donors from Sweden and Denmark from the years 1968 and 1981, respectively. Only data from Sweden were used for these analyses. Information on fractures was obtained by linking SCANDAT2 to hospital registers. Poisson regression was used to compute incidence rate ratios of fractures in relation to the cumulative number of apheresis donations, both overall and in fixed time windows. RESULTS In total, 140,289 apheresis donors (67,970 women and 72,319 men) were identified from the SCANDAT2 database and were followed for up to 23 years. We observed no association between the frequency of apheresis donation and the risk of fracture either in the overall study period or during fixed-length time windows. The incidence rate ratio of fractures in donors who had made 100 or more cumulative apheresis donations was 0.99 (95% confidence interval, 0.92-1.06) compared with donors who had made from 9 to 24 donations. The results were similar in analyses stratified by sex and restricted to postmenopausal women. CONCLUSIONS The absence of an association between repeated apheresis donation and fracture risk indicates that apheresis collection is safe with regard to bone health. |
| Databáze: | OpenAIRE |
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