Macular optical coherence tomography in patients with unilateral optic nerve hypoplasia
| Autor: | Gui Shuaung Ying, Norman P. Blair, Lawrence M. Kaufman, Mahnaz Shahidi, Javaneh Abbasian, Jiayan Huang, Michael P. Blair |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Male
Retinal Ganglion Cells genetic structures Visual Acuity Outer plexiform layer Nerve fiber Article chemistry.chemical_compound Nerve Fibers Optical coherence tomography medicine Humans Macula Lutea Eye Abnormalities Child Ganglion cell layer Retrospective Studies Optic nerve hypoplasia medicine.diagnostic_test business.industry Optic Nerve Retinal Inner limiting membrane Anatomy Unilateral Optic Nerve Hypoplasia medicine.disease eye diseases Ophthalmology medicine.anatomical_structure chemistry Pediatrics Perinatology and Child Health Female sense organs business Tomography Optical Coherence |
| Zdroj: | Journal of American Association for Pediatric Ophthalmology and Strabismus. 19:57-61 |
| ISSN: | 1091-8531 |
| DOI: | 10.1016/j.jaapos.2014.10.025 |
| Popis: | To characterize the extent and location of macular thinning in patients with unilateral optic nerve hypoplasia (ONH) as compared to the contralateral normal eye.The medical records of patients with unilateral ONH who underwent spectral domain optical coherence tomography (SD-OCT) of the macula were retrospectively reviewed. SD-OCT scans were manually segmented by 3 observers in 3 macular regions (superior, central, inferior). Boundaries identified included the inner limiting membrane, the junction between the inner nuclear layer and outer plexiform layer, and the neural retina-retinal pigment epithelium interface. Using custom MATLAB software, inner and outer retinal thickness profiles were quantified. A paired t test was used to compare the retinal thickness between the ONH eye and the contralateral normal eyes.Inner retinal thickness of the ONH eye was decreased in all areas of the macula (superior, central, and inferior) compared to the contralateral normal eye (P0.05). Outer retinal thicknesses were also decreased in the central and inferior sections compared with the normal eye (P0.05).Optic nerve hypoplasia is a congenital disease known to result in thinning of the nerve fiber and ganglion cell layer. Our small cohort demonstrated thinning of the inner retinal layers as well as the outer retinal layers in the ONH eye compared with the contralateral normal eye. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect