Methylmercury Exposure and Adverse Cardiovascular Effects in Faroese Whaling Men
| Autor: | Maria Skaalum Petersen, Esben Budtz-Jørgensen, Pal Weihe, Jukka T. Salonen, Hans Petur Nielsen, Katsuyuki Murata, Poul J. Jørgensen, Jórun Askham, Anna L. Choi, Tomi-Pekka Tuomainen, Philippe Grandjean |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Male
Health Toxicology and Mutagenesis Denmark evoked potentials pilot whale Blood Pressure 010501 environmental sciences 01 natural sciences chemistry.chemical_compound 0302 clinical medicine Heart Rate neurotoxicity Atlantic Islands 030212 general & internal medicine seafood Methylmercury food and beverages methylmercury Methylmercury Compounds Middle Aged Whales Pilot food contamination language Regression Analysis Adult medicine.medical_specialty Meat Carotid Artery Common Food Contamination evokes p0tentials Biology 03 medical and health sciences Faroese Environmental health medicine Neurotoxicity Evoked Potentials Auditory Brain Stem Animals Humans Whaling 0105 earth and related environmental sciences Aged Research Public Health Environmental and Occupational Health Fish consumption language.human_language Carotid artery.common Surgery Increased risk chemistry Nails cardiovascular physiology Tunica Intima Hair |
| Zdroj: | Environmental Health Perspectives Choi, A L, Weihe, P, Budtz-Jørgensen, E, Jørgensen, P J, Salonen, J T, Tuomalainen, T-P, Murata, K, Nielsen, H P, Petersen, M S, Askham, J & Grandjean, P 2009, ' Methylmercury exposure and adverse cardiovascular effects in Faroese whalingmen ', Environmental Health Perspectives, vol. 117, no. 3, pp. 367-372 . https://doi.org/10.1289/ehp.11608 University of Copenhagen |
| ISSN: | 1552-9924 0091-6765 |
| DOI: | 10.1289/ehp.11608 |
| Popis: | Udgivelsesdato: 2009 BACKGROUND: Methylmercury (MeHg), a worldwide contaminant found in fish and seafood, has been linked to an increased risk of cardiovascular mortality. OBJECTIVE: We examined 42 Faroese whaling men (30-70 years of age) to assess possible adverse effects within a wide range of MeHg exposures from consumption of pilot whale meat. METHODS: We assessed exposure levels from mercury analysis of toenails and whole blood (obtained at the time of clinical examination), and a hair sample collected 7 years previously. Outcome measures included heart rate variability (HRV), blood pressure (BP), common carotid intima-media thickness (IMT), and brainstem auditory evoked potentials (BAEP). We carried out multiple regression and structural equation model (SEM) analyses to determine the confounder-adjusted effect of mercury exposure. Taking into account correlations among related measures, we categorized exposure and outcomes in groups to derive latent exposure and response variables in SEMs. We used multiple regression analysis to compare the predictive validity of individual exposure biomarkers and the latent exposure variable on individual and latent outcomes. RESULTS: The toenail mercury concentrations varied widely and had a geometric mean of 2.0 microg/g; hair concentrations averaged about 3-fold higher. Mercury exposure was significantly associated with increased BP and IMT. This effect was reflected by SEMs, but mercury in toenails tended to be the best effect predictor. CONCLUSIONS: The results support the notion that increased MeHg exposure promotes the development of cardiovascular disease. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|