Diagnostic accuracy of 99Tcm-HIDA with cholecystokinin and gallbladder ejection fraction in acalculous gallbladder disease
| Autor: | G W Middleton, J H Williams |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Gallbladder disease Gallbladder Diseases Scintigraphy Gastroenterology Internal medicine Humans Medicine Cholecystectomy Radiology Nuclear Medicine and imaging Prospective Studies Radionuclide Imaging Prospective cohort study Cholecystokinin Ejection fraction medicine.diagnostic_test business.industry Gallbladder Ultrasound Technetium Tc 99m Lidofenin General Medicine medicine.disease Surgery medicine.anatomical_structure Female Bile Ducts Radiopharmaceuticals business Follow-Up Studies |
| Zdroj: | Nuclear Medicine Communications. 22:657-661 |
| ISSN: | 0143-3636 |
| DOI: | 10.1097/00006231-200106000-00009 |
| Popis: | The diagnostic accuracy and clinical impact of 99Tcm hepatic iminodiacetic acid (HIDA) imaging with cholecystokinin (CCK) was investigated in a prospective study of 359 patients over an 11 year period. All patients presented with right upper quadrant biliary type pain and had a normal ultrasound investigation prior to imaging. CCK was administered as a 3 min infusion at peak gallbladder uptake of HIDA. A gallbladder ejection fraction (GBEF) was used to quantify the gallbladder response to CCK. Two hundred and forty-four of 359 (68%) patients had an abnormal GBEF (or = 35%). One hundred and thirty-four of 141 (95%) patients who underwent cholecystectomy had abnormal surgical/histological findings and/or relief of symptoms on long-term (mean 5.7 years) follow-up. Clinical follow-up, mean of 5.9 years, of the patients with GBEF35% showed 73/79 (92%) of them with little evidence of gallbladder disease. For a total 261 patients with mean clinical follow-up of 5.7 years the sensitivity of GBEF measurement is 95%, specificity is 92% and overall accuracy is 94%. It is concluded that 99Tcm-HIDA imaging, with a 3 min infusion of CCK, is a highly accurate technique and valuable in the diagnostic management of patients with suspected acalculous gallbladder disease. |
| Databáze: | OpenAIRE |
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