Loss of p16 expression is of prognostic significance in locally advanced prostate cancer: an analysis from the Radiation Therapy Oncology Group protocol 86-10
| Autor: | William U. Shipley, Chin-Lee Wu, Paul Okunieff, James Fontanesi, Elizabeth H. Hammond, Arnab Chakravarti, Miljenko V. Pilepich, A. Pollack, Harvey B. Wolkov, Ross A. Abrams, Jerome R. Cox, M. Roach, K. Heydon |
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| Rok vydání: | 2003 |
| Předmět: |
Oncology
Adult Male Cancer Research medicine.medical_specialty medicine.medical_treatment Regulator Locally advanced Disease-Free Survival Prostate cancer Prostate Predictive Value of Tests Internal medicine Medicine Humans Neoplasm Metastasis Gene Cyclin-Dependent Kinase Inhibitor p16 Aged Proportional Hazards Models Chi-Square Distribution business.industry Retinoblastoma Prostatic Neoplasms Cell cycle Middle Aged medicine.disease Prognosis Immunohistochemistry Survival Analysis Radiation therapy medicine.anatomical_structure Disease Progression business |
| Zdroj: | Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 21(17) |
| ISSN: | 0732-183X |
| Popis: | Purpose: The retinoblastoma (RB) cell cycle regulatory pathway is known to be deregulated in virtually all known human tumors. The protein product of the RB gene, pRB, and its upstream regulator, p16, are among the most commonly affected members of this pathway. We investigated the prognostic significance of both pRB and p16 expression in locally advanced prostate cancers, from patients treated on the Radiation Therapy Oncology Group (RTOG) protocol 86–10. Materials and Methods: Sixty-seven cases from RTOG 86–10 had immunohistochemically stained slides, judged interpretable for both p16 and pRB, available for analysis. Median follow-up was 8.9 years (range, 6.0 to 11.8 years) for surviving patients. Staining for each marker was then correlated with overall survival, local progression, distant metastasis, and disease-specific survival. Results: Loss of p16 expression, as defined by expression was significantly associated with reduced overall survival (P = .039), disease-specific survival (P = .006), and higher risk of local progression (P = .0007) and distant metastasis (P = .026) in the univariate analysis. In the multivariate analysis, loss of p16 was significantly associated with reduced disease-specific survival (P = .0078) and increased risk of local failure (P = .0035) and distant metastasis (P = .026). A borderline association with reduced overall survival (P = .07) was also evident. Loss of pRB was associated with improved disease-specific survival on univariate (P = .028) and multivariate analysis (P = .043), but carried no other significant outcome associations. Conclusion: Loss of p16 is significantly associated with adverse clinical outcome in cases of locally advanced prostate cancer. |
| Databáze: | OpenAIRE |
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