Treatment of Intracerebral Glioblastomas with G422 Tumour Cell Vaccine in a Mouse Model
| Autor: | Hong-Tian Yao, Ma Yh, Ren-Ya Zhan, J S Zheng, J Yu |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Injections
Subcutaneous medicine.medical_treatment Cell Mice Inbred Strains Cancer Vaccines Immunotherapy Adoptive Biochemistry Interferon-gamma Mice Immune system Interferon Cell Line Tumor medicine Animals Cytotoxic T cell Gene Brain Neoplasms business.industry Biochemistry (medical) Cell Biology General Medicine Immunotherapy medicine.disease Genetically modified organism Disease Models Animal medicine.anatomical_structure Immunology B7-1 Antigen Female Glioblastoma business T-Lymphocytes Cytotoxic medicine.drug |
| Zdroj: | Journal of International Medical Research. 36:308-313 |
| ISSN: | 1473-2300 0300-0605 |
| DOI: | 10.1177/147323000803600213 |
| Popis: | The aim of this study was to develop a tumour vaccine with the ability to induce and expand higher affinity cytotoxic T lymphocytes and stimulate an effective antitumour immune response. The hypothesis tested was that G422 glioblastoma cells modified with B7-1 and interferon (IFN)-γ genes could serve as a tumour vaccine. It was found that therapeutic subcutaneous immunizations with this tumour vaccine significantly induced a cytotoxic T-cell response and prolonged the survival of female Kuming mice with intracerebral G422 tumour isografts. The data collectively suggested that G422 glioblastoma cells genetically modified with B7-1 and IFN-γ genes could serve as a tumour vaccine. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|