Morphological assessment of the luminal surface of olfactory epithelium in mice deficient in tissue plasminogen activator following bulbectomy
| Autor: | Shigeo Ookawara, Nobuko Makino, Takeharu Kanazawa, Toshio Ishikawa, Masumi Ichikawa, Jun Mimuro, Osamu Matsuo, Yoichi Sakata, Keiichi Ichimura, Yasushi Ohta, Kazuo Katoh, Seiji Madoiwa, Shu Takigami |
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| Rok vydání: | 2012 |
| Předmět: |
Pathology
medicine.medical_specialty Plasmin business.industry Regeneration (biology) General Medicine Olfaction Olfactory Bulb Tissue plasminogen activator Olfactory bulb Mice Inbred C57BL Mice medicine.anatomical_structure Microscopy Electron Transmission Olfactory Mucosa Otorhinolaryngology Tissue Plasminogen Activator medicine Animals Regeneration Neuron business Receptor Olfactory epithelium medicine.drug |
| Zdroj: | The Journal of Laryngology & Otology. 126:1114-1120 |
| ISSN: | 1748-5460 0022-2151 |
| DOI: | 10.1017/s002221511200206x |
| Popis: | Objective:This study aimed to investigate the function of tissue plasminogen activator in the olfactory epithelium of mice following neural injury.Method:Transmission electron microscopy was used to study the changes in the morphology of the olfactory epithelium 1–7 days after surgical ablation of the olfactory bulb (bulbectomy).Results:Prior to bulbectomy, a uniformly fine material was observed within some regions of the olfactory epithelium of mice deficient in tissue plasminogen activator. At 2–3 days after bulbectomy, there were degenerative changes in the olfactory epithelium. At 5–7 days after bulbectomy, we noted drastic differences in olfactory epithelium morphology between mice deficient in tissue plasminogen activator and wild-type mice (comparisons were made using findings from a previous study). The microvilli seemed to be normal and olfactory vesicles and receptor neuron dendrites were largely intact in the olfactory epithelium of mice deficient in tissue plasminogen activator.Conclusion:The tissue plasminogen activator plasmin system may inhibit the regeneration of the olfactory epithelium in the early stages following neural injury. |
| Databáze: | OpenAIRE |
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