Modelling the Innate Immune Response against Avian Influenza Virus in Chicken
| Autor: | Hagenaars, T J, Fischer, E A J, Jansen, C A, Rebel, J M J, Spekreijse, D, Vervelde, L, Backer, J A, de Jong, M.C.M., Koets, A P, LS GZ Landbouwhuisdieren, LS Immunologie, Sub Immunologie, dFAH I&I |
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| Přispěvatelé: | LS GZ Landbouwhuisdieren, LS Immunologie, Sub Immunologie, dFAH I&I |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Epidemiology Kwantitatieve Veterinaire Epidemiologie lcsh:Medicine Apoptosis NK cells medicine.disease_cause Lymphocyte Activation Biochemistry Diagnostics & Crisis Organization Dierenwelzijn en gezondheid Cellular types Influenza A virus lcsh:Science Immune Response Multidisciplinary Diagnostiek & Crisisorganisatie Cell Death Pharmaceutics Bacteriologie Immune cells Degranulation Bacteriology Host Pathogen Interaction & Diagnostics Animal Models Viral Load Killer Cells Natural Cell Processes White blood cells RNA Viral Viral load Research Article Cell biology Blood cells Bioinformatica & Diermodellen 030106 microbiology Immunology Biology Research and Analysis Methods Microbiology 03 medical and health sciences Immune system Dose Prediction Methods Model Organisms Exponential growth Immunity Virology Bio-informatics & Animal models medicine Life Science Animals Epidemiology Bio-informatics & Animal models Animal Health & Welfare Least-Squares Analysis Host Pathogen Interaction & Diagnostics Epidemiologie Medicine and health sciences Innate immune system lcsh:R Models Immunological Virion Quantitative Veterinary Epidemiology Biology and Life Sciences Proteins Bacteriology Influenza A virus subtype H5N1 Host Pathogen Interactie & Diagnostiek Immunity Innate Chicken Models 030104 developmental biology Animal cells Epidemiologie Bioinformatica & Diermodellen Influenza in Birds Bacteriologie Host Pathogen Interactie & Diagnostiek WIAS Linear Models lcsh:Q Interferons Chickens Viral Transmission and Infection |
| Zdroj: | PLoS ONE PLoS ONE, Vol 11, Iss 6, p e0157816 (2016) PLoS ONE 11 (2016) 6 PLoS ONE, 11(6) Hagenaars, T J, Fischer, E A J, Jansen, C A, Rebel, J M J, Spekreijse, D, Vervelde, L, Backer, J A, de Jong, M C M & Koets, A P 2016, ' Modelling the Innate Immune Response against Avian Influenza Virus in Chicken ', PLoS ONE, vol. 11, no. 6, e0157816 . https://doi.org/10.1371/journal.pone.0157816 PLoS One, 11(6). Public Library of Science |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0157816 |
| Popis: | At present there is limited understanding of the host immune response to (low pathogenic) avian influenza virus infections in poultry. Here we develop a mathematical model for the innate immune response to avian influenza virus in chicken lung, describing the dynamics of viral load, interferon-α, -β and -γ, lung (i.e. pulmonary) cells and Natural Killer cells. We use recent results from experimentally infected chickens to validate some of the model predictions. The model includes an initial exponential increase of the viral load, which we show to be consistent with experimental data. Using this exponential growth model we show that the duration until a given viral load is reached in experiments with different inoculation doses is consistent with a model assuming a linear relationship between initial viral load and inoculation dose. Subsequent to the exponential-growth phase, the model results show a decline in viral load caused by both target-cell limitation as well as the innate immune response. The model results suggest that the temporal viral load pattern in the lungs displayed in experimental data cannot be explained by target-cell limitation alone. For biologically plausible parameter values the model is able to qualitatively match to data on viral load in chicken lungs up until approximately 4 days post infection. Comparison of model predictions with data on CD107-mediated degranulation of Natural Killer cells yields some discrepancy also for earlier days post infection. |
| Databáze: | OpenAIRE |
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