Resveratrol suppresses bone cancer pain in rats by attenuating inflammatory responses through the AMPK/Drp1 signaling
| Autor: | Miao-Miao Hao, Jieqiong Ding, Qiong Tang, Bang-Hua Wang, Ming-Yue Li, Yisheng Li, Min Xie, Haili Zhu |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Dynamins
0301 basic medicine Biophysics Pain Bone Neoplasms Inflammation AMP-Activated Protein Kinases Mitochondrion Resveratrol Mitochondrial Dynamics Biochemistry Proinflammatory cytokine Rats Sprague-Dawley 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Cell Line Tumor medicine Animals Osteosarcoma Bone cancer Chemistry Bone metastasis AMPK Cancer Pain General Medicine medicine.disease Mitochondria Rats 030104 developmental biology Spinal Cord Hyperalgesia Astrocytes Cancer research Female Tumor necrosis factor alpha medicine.symptom 030217 neurology & neurosurgery Signal Transduction |
| Zdroj: | Acta Biochimica et Biophysica Sinica. 52:231-240 |
| ISSN: | 1672-9145 |
| DOI: | 10.1093/abbs/gmz162 |
| Popis: | Bone cancer pain (BCP) is induced by primary bone cancer and secondary bone metastasis. During BCP pathogenesis, activated spinal astrocytes release proinflammatory cytokines, which participate in pain information transmission. In this study, we found that BCP rats showed disruption of trabecular bone structure, mechanical allodynia, and spinal inflammation. Moreover, reduced adenosine monophosphate-activated protein kinase (AMPK) activity, increased mitochondrial fission-associated protein Drp1 GTPase activity accompanied by the dysfunction of mitochondrial function, and abnormal BAX and Bcl-2 expression were found in the spinal cord of BCP rats. Notably, these alterations are reversed by resveratrol (Res) administration. Cell experiment results demonstrated that Res promotes mitochondrial function by activating AMPK, decreasing Drp1 activity, and inhibiting tumor necrosis factor-α-induced mitochondrial membrane potential reduction. Taken together, these results indicate that Res suppresses BCP in rats by attenuation of the inflammatory responses through the AMPK/Drp1 signaling pathway. |
| Databáze: | OpenAIRE |
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