THE EFFICACY OF NEDOCROMIL SODIUM (TILADE®) IN ASTHMA
| Autor: | Abe R. Rubinfeld, J H Alpers, Daniel Czarny, M. C. F. Pain, Richard E. Ruffin, Glenn Bowes |
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| Rok vydání: | 1987 |
| Předmět: |
Adult
Male Drug Nedocromil Adolescent medicine.drug_class media_common.quotation_subject Placebo law.invention Double-Blind Method Randomized controlled trial law Bronchodilator Administration Inhalation Internal Medicine medicine Humans Nedocromil Sodium Aged media_common Asthma Clinical Trials as Topic Inhalation business.industry Beclomethasone Middle Aged respiratory system medicine.disease respiratory tract diseases Anesthesia Quinolines Female Pulmonary Ventilation business medicine.drug |
| Zdroj: | Australian and New Zealand Journal of Medicine. 17:557-561 |
| ISSN: | 0004-8291 |
| DOI: | 10.1111/j.1445-5994.1987.tb01255.x |
| Popis: | Nedocromil sodium is a new antiasthmatic drug with properties similar to sodium cromoglycate. We examined the efficacy of nedocromil sodium compared to placebo in 71 asthmatic patients in a three-centre double-blind parallel group study over 12 weeks. During the study the patients' maintenance inhaled corticosteroids were progressively withdrawn. Nedocromil sodium had an advantage over placebo in the number of withdrawals related to uncontrolled asthma, 14 and 24 respectively (p = 0.03). Changes in symptom scores, peak flow rates and bronchodilator use favoured nedocromil sodium occasionally during the study. The unusual taste of the active drug was reported frequently. Nedocromil sodium is more efficacious than placebo in asthma maintenance, but does not replace inhaled corticosteroids. |
| Databáze: | OpenAIRE |
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