The association between serum albumin/prealbumin level and disease severity in non‐CF bronchiectasis

Autor:	Liyang Li, Sijiao Wang, Huayin Li, Yuanlin Song, Jing Bi, Changzhou Shao, Zhuozhe Li
Rok vydání:	2020
Předmět:	Adult Male 0301 basic medicine medicine.medical_specialty Physiology Serum albumin Serum Albumin Human Severity of Illness Index Gastroenterology Pulmonary function testing 03 medical and health sciences 0302 clinical medicine Quality of life Predictive Value of Tests Surveys and Questionnaires Physiology (medical) Internal medicine medicine Humans Prealbumin Medical history Lung Aged Retrospective Studies Pharmacology COPD Bronchiectasis biology business.industry Albumin nutritional and metabolic diseases Middle Aged Prognosis medicine.disease Respiratory Function Tests Cross-Sectional Studies 030104 developmental biology 030220 oncology & carcinogenesis Quality of Life biology.protein Female business Body mass index Biomarkers
Zdroj:	Clinical and Experimental Pharmacology and Physiology. 47:1537-1544
ISSN:	1440-1681 0305-1870
DOI:	10.1111/1440-1681.13331
Popis:	Non-cystic fibrosis (non-CF) bronchiectasis is a chronic pulmonary disease that can lead to malnutrition. Serum prealbumin and albumin level are related to inflammatory and nutritional status. Thus, we aimed to confirm our hypothesis that low serum albumin and prealbumin level, as well as body mass index (BMI), is correlated to severe non-CF bronchiectasis. We conducted a retrospective cross-sectional study of 128 patients, including 75 patients with prealbumin test and 79 patients with albumin test. Detailed medical history was recorded, including pulmonary function tests and high-resolution computed tomography. bronchiectasis severity index (BSI) and FACED scores were calculated. Leicester Cough Questionnaire, Quality of Life Questionnaire-Bronchiectasis, chronic obstructive pulmonary disease (COPD) assessment test and Patient Health Questionnaire-9 questionnaires were used to assess patients' clinical symptoms. Correlation analysis showed that BSI score was more correlated to patients' clinical symptoms than FACED. Thus, patients were divided into three groups of different severity based on BSI score. Albumin, prealbumin and BMI showed a significant difference between three groups. Correlation and multivariable linear regression analysis showed that serum albumin and prealbumin level were correlated to BSI, FACED and questionnaires. The analysis between three indices and PFT/high-resolution computed tomography (HRCT) showed that prealbumin, albumin and BMI could reflect the PFT and modified Reiff score in non-CF bronchiectasis. In conclusion, BMI, albumin and prealbumin showed a significant correlation with the BSI, FACED, as well as patients' clinical symptoms. Among them, serum albumin was the indicator most strongly associated with the BSI and questionnaires, while prealbumin could better reflect lung function decline and radiological severity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54715bcc51d9934cf14845bac5ddb01f https://doi.org/10.1111/1440-1681.13331 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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