Technetium-labeled danofloxacin complex as a model for infection imaging
| Autor: | Hoda A. Shweeta, M. A. Motaleb, Moustapha E. Moustapha |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
Biodistribution
Chemistry(all) Danofloxacin medicine.drug_class General Chemical Engineering Antibiotics chemistry.chemical_element Inflammation Pharmacology 010403 inorganic & nuclear chemistry Technetium 01 natural sciences 030218 nuclear medicine & medical imaging lcsh:Chemistry Lesion 03 medical and health sciences 0302 clinical medicine Pharmacokinetics Labeling Diagnosis medicine Abscess GeneralLiterature_REFERENCE(e.g. dictionaries encyclopedias glossaries) ComputingMilieux_MISCELLANEOUS General Chemistry medicine.disease 0104 chemical sciences lcsh:QD1-999 chemistry Chemical Engineering(all) medicine.symptom Infection medicine.drug |
| Zdroj: | Arabian Journal of Chemistry, Vol 9, Iss S2, Pp S1928-S1934 (2016) |
| ISSN: | 1878-5352 |
| DOI: | 10.1016/j.arabjc.2014.10.017 |
| Popis: | Danofloxacin, a fluoroquinolone derivative antibiotic, was synthesized, successfully labeled with technetium-99m and formulated for the development of a potential diagnostic imaging agent of the bacterial infection and inflammation with higher efficiency than that of the commercially available 99mTc-ciprofloxacin. Factors affecting the labeling yield were optimized. The radiolabeled antibiotic was subjected to preclinical assessments such as purity, stability, and pharmacokinetic investigations in animals. The biodistribution studies indicated that the uptake of 99mTc-danofloxacin was high in the infectious lesion (T/NT = 7.2 ± 0.1) at 2 h post injection. The abscess to normal ratio indicated that the danofloxacin tracer can be used for infection diagnosis. The radiolabeled compound was cleared quickly from most of the body organs. The results displayed that 99mTc-danofloxacin could not differentiate between infection and sterile inflammation. |
| Databáze: | OpenAIRE |
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