Evaluation of sequence variability in HIV-1 gp41 C-peptide helix-grafted proteins

Autor:	Rachel L. Tennyson, Susanne N. Walker, Brian R. McNaughton, Terumasa Ikeda, Reuben S. Harris
Rok vydání:	2017
Předmět:	0301 basic medicine Scaffold protein Clinical Biochemistry Pharmaceutical Science Trimer Yeast display Gp41 01 natural sciences Biochemistry Protein Structure Secondary Article Cell Line 03 medical and health sciences Peptide Library Drug Discovery Humans Amino Acid Sequence Molecular Biology Helix bundle 010405 organic chemistry Chemistry Circular Dichroism Organic Chemistry Protein engineering Blood Proteins Virus Internalization Phosphoproteins HIV Envelope Protein gp41 0104 chemical sciences 030104 developmental biology Helix HIV-1 Molecular Medicine Peptides Alpha helix Protein Binding
Zdroj:	Bioorganicmedicinal chemistry. 26(6)
ISSN:	1464-3391
Popis:	Many therapeutically-relevant protein-protein interactions (PPIs) have been reported that feature a helix and helix-binding cleft at the interface. Given this, different approaches to disrupting such PPIs have been developed. While short peptides (
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::546a720629c12702ffcb6e47cd838edb https://pubmed.ncbi.nlm.nih.gov/28811070 Zobrazit plný text záznamu Full Text from ScienceDirect