Leucine Kinetics during Simultaneously Administered Insulin and Dexamethasone in Preterm Infants with Severe Lung Disease
| Autor: | L. J. Zimmermann, R. H. T. van Beek, J. G. Vergunst van Keulen, J.B. van Goudoever, Pjj Sauer, Darcos J L Wattimena, Virgilio P. Carnielli |
|---|---|
| Přispěvatelé: | Other departments |
| Rok vydání: | 2001 |
| Předmět: |
Lung Diseases
medicine.medical_specialty medicine.drug_class medicine.medical_treatment Anti-Inflammatory Agents Dexamethasone Leucine Internal medicine Humans Hypoglycemic Agents Infant Very Low Birth Weight Insulin Medicine Drug Interactions Pancreatic hormone business.industry Infant Newborn Metabolism Endocrinology Pediatrics Perinatology and Child Health Corticosteroid medicine.symptom business Weight gain Infant Premature Hormone medicine.drug |
| Zdroj: | Pediatric research, 49(3), 373-378. Lippincott Williams and Wilkins |
| ISSN: | 1530-0447 0031-3998 |
| DOI: | 10.1203/00006450-200103000-00011 |
| Popis: | The objective of this study was to determine whether insulin administration would prevent the well-documented catabolic effect of dexamethasone given to preterm infants with chronic lung disease. We studied leucine metabolism in 11 very-low-birth-weight infants before dexamethasone treatment and on d 2, 4, and 7 thereafter. During the first 4 d of dexamethasone, insulin was administered i.v. at a dose of 0.5 (n = 7) or 1.0 (n = 5) IU/kg/d. Leucine turnover was not significantly different between d 0 (337 +/- 41.3 micromol leucine/kg/h), d 2 (288 +/- 27.2 micromol leucine/kg/h), d 4 (302 +/- 22.1 micromol leucine/kg/h), and d 7 (321 +/- 21.2 micromol leucine/kg/h), and neither was leucine breakdown (272 +/- 21.9 micromol leucine/kg/h on d 0, 225 +/- 21.5 micromol leucine/kg/h on d 2, 231 +/- 21 micromol leucine/kg/h on d 4, and 242 +/- 17.6 micromol leucine/kg/h on d 7). Weight gain rates were significantly lower during the first week of dexamethasone treatment compared with the week before treatment or the second and third week. We conclude that during insulin and corticosteroid administration in very-low-birth-weight infants, no changes were observed in leucine kinetics in contrast to previous studies. The decrease in weight gain was not reversed. |
| Databáze: | OpenAIRE |
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