Mediators of lifestyle intervention effects on neonatal adiposity

Autor: Lima, Rodrigo Antunes, Desoye, Gernot, Simmons, David, van Poppel, Mireille Nicoline Maria, Devlieger, Roland, Galjaard, Sander, Corcoy, Rosa, Adelantado, Juan M., Dunne, Fidelma, Harreiter, Jürgen, Kautzky-Willer, Alexandra, Damm, Peter, Mathiesen, Elisabeth R., Jensen, Dorte M., Andersen, Lise Lotte, Tanvig, Mette, Lapolla, Annunziata, Dalfra, Maria Grazia, Bertolotto, Alessandra, Wender-Ozegowska, Ewa, Zawiejska, Agnieszka, Hill, David J., Snoek, Frank J., Jelsma, Judith G.M.
Přispěvatelé: Obstetrics & Gynecology, Medical psychology, APH - Health Behaviors & Chronic Diseases, APH - Mental Health, Amsterdam Reproduction & Development (AR&D), Public and occupational health, Medical Psychology
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Lima, R A, Desoye, G, Simmons, D, van Poppel, M N M, On behalf of The DALI core investigator group, Damm, P, Mathiesen, E R, Jensen, D M, Andersen, L L & Tanvig, M 2022, ' Mediators of lifestyle intervention effects on neonatal adiposity : are we missing a piece of the puzzle? ', Pediatric Research, vol. 91, no. 3, pp. 522-525 . https://doi.org/10.1038/s41390-021-01450-5
Pediatric Research, 91(3), 522-525. Lippincott Williams & Wilkins
Pediatric Research. Lippincott Williams and Wilkins
Pediatric research. Lippincott Williams and Wilkins
On behalf of the DALI Core Investigator group 2021, ' Mediators of lifestyle intervention effects on neonatal adiposity : are we missing a piece of the puzzle? ', Pediatric Research . https://doi.org/10.1038/s41390-021-01450-5
ISSN: 1530-0447
0031-3998
Popis: We evaluated possible mediators underlying lifestyle intervention effects on neonatal adiposity, assessed with sum of skinfolds and cord blood leptin. This is a secondary analysis of the DALI study, a randomised controlled trial in nine European countries. Pregnant women with a pre-pregnancy body mass index of ≥29 kg/m2 were randomly assigned to counselling for healthy eating (HE), physical activity (PA), HE&PA combined, or to usual care. We considered five maternal metabolic factors at 24–28 and 35–37 weeks of gestation, and four cord blood factors as possible mediators of the effect of combined HE&PA counselling on neonatal adiposity. From all potential mediators, the intervention only affected cord blood non-esterified fatty acids (NEFA), which was higher in the HE&PA group compared to UC (0.068 (mmol/L), 95% CI: 0.004 to 0.133). Cord blood NEFA did not mediate the HE&PA intervention effects on neonatal sum of skinfolds or cord blood leptin, based on an indirect effect on skinfolds of 0.018 (mm), 95% CI: −0.217 to 0.253 and an indirect effect on leptin of −0.143 (μg/l), 95% CI: −0.560 to 0.273. The Dali study observed reductions in neonatal adiposity in pregnant women with obesity, but we were not able to identify the underlying metabolic pathway.
Databáze: OpenAIRE
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