Hyper-responsivity to stress in rats is associated with a large increase in amygdala volume. A 7T MRI study
| Autor: | Julie Bourgin, Sébastien Mériaux, Thérèse M. Jay, M. Bottlaender, Fawzi Boumezbeur, B. Djemaï, Arnaud Cachia, Edouard Duchesnay |
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| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty F344 rats Amygdala Hippocampus Stress (mechanics) Rats Sprague-Dawley Neuroimaging Species Specificity Internal medicine medicine Animals Pharmacology (medical) Prefrontal cortex Isotropic resolution Biological Psychiatry Pharmacology Analysis of Variance Electroencephalography Magnetic Resonance Imaging Rats Inbred F344 Rats Psychiatry and Mental health Disease Models Animal medicine.anatomical_structure Pharmacological interventions Endocrinology Neurology Neurology (clinical) Psychology Corticosterone Neuroscience Ex vivo Stress Psychological |
| Zdroj: | European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 25(6) |
| ISSN: | 1873-7862 |
| Popis: | Stress is known to precipitate psychiatric disorders in vulnerable people. Individual differences in the stress responsivity can dramatically affect the onset of these illnesses. Animal models of repeated stress represent valuable tools to identify region-specific volumetric changes in the brain. Here, using high resolution 7 T MRI, we found that amygdala is the most significant parameter for distinction between F344 and SD rats known to have differential response to stress. A significant substantial increase (45%) was found in the amygdala volume of rats that do not habituate to the repeated stress procedure (F344 rats) compared to SD rats. This strain-specific effect of stress was evidenced by a significant strain-by-stress interaction. There were no significant strain differences in the volumes of hippocampi and prefrontal cortices though stress produces significant reductions of smaller amplitude in the medial prefrontal cortex (mPFC) (9% and 12%) and dorsal hippocampus (5% and 6%) in both strains. Our data further demonstrate the feasibility and relevance of high isotropic resolution structural ex vivo 7 T MRI in the study of the brain effects of stress in small animals. Neuroimaging is a valuable tool to follow up brain volumetric reorganization during the stress response and could also be easily used to test pharmacological interventions to prevent the deleterious effects of stress. |
| Databáze: | OpenAIRE |
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