Heparin coupled to albumin, dextran and ficoll: influence on blood coagulation and platelets, and in vivo duration
| Autor: | Arne N. Teien, Ole Rasmus Ødegård, Terje B. Christensen |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
Platelet Aggregation
medicine.drug_class Ficoll Pharmacology chemistry.chemical_compound In vivo Polysaccharides medicine Animals Humans Platelet Blood Coagulation Serum Albumin Heparin Anticoagulant Albumin Temperature Dextrans Thrombosis Hematology Dextran Coagulation chemistry Biochemistry Rabbits medicine.drug |
| Zdroj: | Thrombosis research. 7(2) |
| ISSN: | 0049-3848 |
| Popis: | Heparin coupled to albumin, ficoll and dextran by the CNBr method exerts anticoagulant and blood platelet aggretating effects which deviate from that of free heparin. Heparin-albumin complex had the same anticoagulant and aggregating effect as heparin. Heparin-dextran complex had a weaker anticoagulant and aggregating effect than heparin. Heparin-ficoll complex had the same effect as heparin in the thrombin clotting time and Thrombotest systems, but a stronger anticoagulant effect in the APTT-system, and a weaker platelet aggregating effect than heparin. After intra venous injection in rabbits, the half life of the heparin-albumin, heparin-dextran and heparin-ficoll complexes were about 120, 110 and 160 per cent, respectively, of the half life of uncomplexed heparin. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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