Significance of fucose in intestinal health and disease
| Autor: | Garber, Jolene M, Hennet, Thierry, Szymanski, Christine M |
|---|---|
| Přispěvatelé: | University of Zurich, Hennet, Thierry, Szymanski, Christine M |
| Rok vydání: | 2021 |
| Předmět: |
Glycosylation
Disease outcome 610 Medicine & health Disease Biology medicine.disease_cause Microbiology Fucose 10052 Institute of Physiology Mice 03 medical and health sciences chemistry.chemical_compound 1312 Molecular Biology Dietary Carbohydrates medicine Animals Humans Microbiome Intestinal Mucosa Molecular Biology Fucosylation 030304 developmental biology 0303 health sciences Gastrointestinal tract Bacteria Host Microbial Interactions 030306 microbiology Campylobacter 2404 Microbiology biology.organism_classification Gastrointestinal Microbiome Gastrointestinal Tract chemistry 570 Life sciences biology Bacteroides |
| Zdroj: | Molecular Microbiology. 115:1086-1093 |
| ISSN: | 1365-2958 0950-382X |
| DOI: | 10.1111/mmi.14681 |
| Popis: | The deoxyhexose sugar L-fucose is important for many biological processes within the human body and the associated microbiota. This carbohydrate is abundant in host gut mucosal surfaces, numerous microbial cell surface structures, and some dietary carbohydrates. Fucosylated oligosaccharides facilitate the establishment of a healthy microbiota and provide protection from infection. However, there are instances where pathogens can also exploit these fucosylated structures to cause infection. Furthermore, deficiencies in host fucosylation are associated with specific disease outcomes. This review focuses on our current understanding of the impact of fucosylation within the mucosal environment of the gastrointestinal tract with a specific emphasis on the mediatory effects in host-microbe interactions. |
| Databáze: | OpenAIRE |
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